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  1. Simon M
    Post

    Tonix Pharmaceuticals begins subject enrolment in migraine therapy trial

    . I think phase 2 is the earliest stage of trial. It’s another drug targeting CGRP, but what makes it interesting is that it directly targets the...
    Post by: Simon M, Feb 7, 2023 at 5:25 PM in forum: Other health news and research
  2. Simon M
    Post

    Thesis: Investigating the Genetic and Immunological Aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2022 Dibble

    Crossed with Chris P I don't claim expertise, but do know that the SNP identified is rarely the active, relevant DNA difference. Usually, it is...
    Post by: Simon M, Feb 6, 2023 at 9:37 AM in forum: ME/CFS research
  3. Simon M
    Post

    No Causal Effects Detected in COVID-19 and ME/CFS: A Two Sample Mendelian Randomization Study 2023 Xu et al

    In his large study of glandular fever, Peter White found that days of bedrest was a predictor of developing CFS. Bedrest is most obviously a...
    Post by: Simon M, Feb 2, 2023 in forum: ME/CFS research
  4. Simon M
    Post

    Can vaccines cure ME/CFS or Long Covid?

    From a recent review on LC: The impact of vaccination on long COVID symptoms in people who had already developed long COVID differs among...
    Post by: Simon M, Jan 30, 2023 in forum: Other treatments
  5. Simon M
    Post

    Thesis: Investigating the Genetic and Immunological Aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2022 Dibble

    Joshua was working in Chris Ponting’s group, and his PhD was jointly funded by Action for. ME and the office of the Scottish chief medical...
    Post by: Simon M, Jan 30, 2023 in forum: ME/CFS research
  6. Simon M
    Post

    Thesis: Investigating the Genetic and Immunological Aetiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome 2022 Dibble

    If I’ve understood right, using best practice mathematical and immunological methods, Joshua did find a single genetic difference that was...
    Post by: Simon M, Jan 30, 2023 in forum: ME/CFS research
  7. Simon M
    Post

    What do people think of SF-36?

    Thank you, I’m glad the issue will be clearly raised. Like many others, I’ve achieved that short term gain under the encouragement of a...
    Post by: Simon M, Jan 18, 2023 in forum: ME/CFS research
  8. Simon M
    Post

    What do people think of SF-36?

    I know you and Adrian do, but unless the research group absolutely locks in subjective outcome measures to use only in blinded trials, I think the...
    Post by: Simon M, Jan 18, 2023 in forum: ME/CFS research
  9. Simon M
    Post

    What do people think of SF-36?

    Thanks. I would much prefer objective measures. but does the research group understand the prolem of using subjective outcomes in non-blinded trials?
    Post by: Simon M, Jan 17, 2023 in forum: ME/CFS research
  10. Simon M
    Post

    What do people think of SF-36?

    It would be helpful to know the purpose of using the sf-36 scale. and apologies if this is posted earlier, I haven't been able to read the whole...
    Post by: Simon M, Jan 17, 2023 in forum: ME/CFS research
  11. Simon M
    Post

    What do people think of SF-36?

    SF-36 Physical Function subscale I actually think the SF 36 scale provides the best available self-report measure of physical function (I'm not...
    Post by: Simon M, Jan 16, 2023 in forum: ME/CFS research
  12. Simon M
    Post

    Converging Evidence of Similar Symptomatology of ME/CFS and PASC Indicating Multisystemic Dyshomeostasis , 2023, Marks

    I’m not sure that such hypothesising based on a large number of generic symptoms gets us anywhere useful. It’s easy to fit just about any...
    Post by: Simon M, Jan 11, 2023 in forum: ME/CFS research
  13. Simon M
    Post

    USA: NIH National Institutes of Health news

    edited I feel I and others with severe ME have a lot to offer ME research projects. At no point in my illness could I have ever done 4 hours, but...
    Post by: Simon M, Jan 9, 2023 in forum: News from organisations
  14. Simon M
    Post

    Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

    @FMMM1 The approach uses combinations of features (in this case between three and 5 SNPs) to create “disease signatures“ that identify a subgroup...
    Post by: Simon M, Dec 19, 2022 in forum: ME/CFS research
  15. Simon M
    Post

    Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

    Key section from the published paper. There are a number of limitations with this study discussed above, and a larger, more detailed longitudinal...
    Post by: Simon M, Dec 16, 2022 in forum: ME/CFS research
  16. Simon M
    Post

    Genetic Risk Factors for ME/CFS Identified using Combinatorial Analysis, 2022, Das et al

    The full paper has now been peer-reviewed and published (open access). Genetic risk factors for ME/CFS identified using combinatorial analysis...
    Post by: Simon M, Dec 15, 2022 in forum: ME/CFS research
  17. Simon M
    Post

    Which scientists and research groups would you want to bring to the ME/CFS research field

    The approach of the Edinburgh Genetics Centre of Excellence and aim of DecodeME is the first find genetic clues pointing to the causes of ME....
    Post by: Simon M, Dec 6, 2022 in forum: ME/CFS research
  18. Simon M
    Post

    Post-exertional symptoms distinguish myalgic encephalomyelitis/chronic fatigue syndrome subjects from healthy controls, 2020, Mateo et al

    Has this been published yet? It would be good to have more detail. E.g. anything over 3 months to recovery I woulc call a relapse. But I am...
    Post by: Simon M, Nov 27, 2022 in forum: ME/CFS research
  19. Simon M
    Post

    Post-exertional symptoms distinguish myalgic encephalomyelitis/chronic fatigue syndrome subjects from healthy controls, 2020, Mateo et al

    Despite being in the field for at leat a decade, CPET researchers are still failing to collect and publish harms data. That is as unacceptable for...
    Post by: Simon M, Nov 25, 2022 in forum: ME/CFS research
  20. Simon M
    Post

    Differences in Symptoms among Black and White Patients with ME/CFS 2022, Jason and Torres

    I think this is the first specific study looking at ethnic differences, which is is a very important area. but I'm not sure how much we can...
    Post by: Simon M, Nov 14, 2022 in forum: ME/CFS research
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