Search results

It would be interesting if we could analyze the data ourselves. The paper writes: Unfortunately, I can't seem to find the data at the mapMECFS repository: has anyone else found it?

Todd Davenport wrote on Twitter: I have no idea what he means by this. If many CPET measurements are collinear with sex and VO2peak, than this simply means that these difference in the measurements could be due to sex or deconditioning rather than ME/CFS. So it would mean that it is important...

Interesting study. Unfortunate that it was not published in a more prominent journal. The results and discussion sections are also quite extensive, making it is hard to find the main data. What I would like to see is a group comparison between the 55 ME/CFS patients and their matched controls...

Abstract Background: Many individuals without coeliac disease or wheat allergy reduce their gluten intake because they believe that gluten causes their gastrointestinal symptoms. Symptoms could be affected by negative expectancy. Therefore, we aimed to investigate the effects of expectancy...

No I don't think so but since the selection of 2 rewards (that were actually paid out) was based on luck, we can look at the mean reward value and see how each participant maximised their actual rewards. This is what I got after a quick calculation. Healthy volunteer F got by far the biggest...

Perhaps because the 4 test trials were still included? Those have a negative trial number and should be removed in the analysis. There is another issue that the rewards that were given are likely those that have a value of 1 for 'Reward_Granted_Yes_is_1' and for 'Successful_Completion_Yes_is_1'...

There is more info on the EEfRT data in this thread: https://www.s4me.info/threads/use-of-eefrt-in-the-nih-study-deep-phenotyping-of-pi-me-cfs-2024-walitt-et-al.37463/page-24#post-520697 Great that you are highlighting this issue. I would like to help out in chat or email to point out the...

These seem to be the main results:

Also from the paper: "Using this symptom scoring system we did not see clear relationships between microclot counts and the presence of symptoms. Around half of the participants had microclot counts similar to the controls but reported the same symptom patterns as those with raised microclots...

Just read this paper. They found a remarkable strong effect for sick leave (GPs recorded sick leave from the participants’ medical records). In the intervention group sick leave dropped from 52% to 25.2%, while in the control group it went from 49.7% to 45.7%.

It is also nearly impossible to discuss this in a rational way because the category is so broad: all long-term somatic symptoms, regardless if they are explained or not. If they claim that 'catastrophising interpretations' or 'somatosensory amplification' are important they can simply point to...

Me too. Very frustrating. So many claims in this article that aren't based on scientific evidence. I suspect some of the Lancet editors and peer reviewers are really biased towards this view otherwise this would never have passed. Take for example statements like these: So a biopsychosocial...

Looks very useful, thanks.

I've posted it in a separate thread here: https://www.s4me.info/threads/the-problems-with-pots-me-cfs-skeptic-blog.39131/

Yes I think the evidence suggests that most patients with ME/CFS have orthostatic intolerance symptoms that are not related to orthostatic tachycardia.

Here's the summary I've posted on Twitter: 1) A new blog post about the problems with Postural Orthostatic Tachycardia Syndrome (POTS) criteria. It’s quite a long read, so I’ll try to summarize the main ideas in this thread. 2) ARGUMENT 1: heart rate increases upon standing > 30 bpm are far...

I've written an overview of the problems with Postural Orthostatic Tachycardia Syndrome (POTS) criteria. https://mecfsskeptic.com/the-problems-with-pots/ A brief summary of the arguments looks like this: A heart rate increase of 30 bpm (or 40 bpm in 12–19-year-olds) is far from abnormal. Many...

Thanks. I've found the Streeten data in his 1987 book which I assume is from the same experiment as the 1988 paper. Orthostatic Disorders of the Circulation: Mechanisms, Manifestations, and ... - David H.P. Streeten - Google Books Interesting paper on diurnal variability. In my view, further...

Thanks. To be honest I don't fully know what to make of it either. Am interested in what others think.

I wrote an overview of the problems I see with the POTS criteria, summarizing the studies posted in this thread. https://mecfsskeptic.com/the-problems-with-pots/ A brief summary of the arguments looks like this: A heart rate increase of 30 bpm (or 40 bpm in 12–19-year-olds) is far from...