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Abstract Study design: A cohort study with 12 months of follow-up. Objective: To assess (1) the unidimensionality of the Fear-Avoidance Beliefs Questionnaire (FABQ) and (2) whether single questions in the FABQ predict future sickness absence as well as the whole scale. Summary of background...

They argue that the optimal R&D investment in Germany was €676 million, which represents only a quarter of the total investment needed to bring a drug to market. They therefore say that international collaboration is necessary. A closer look at their assumptions: - The data on quality of life...

I think these authors have published more dan a dozen of these risk factor papers for CFS based on the Taiwanese insurance research database with a separate paper for each risk factor. I have doubts about the reliability of their database: it is unclear if ME or CFS are recognized diagnoses in...

Noticed that this researcher: Douglas C Youvan has written a comment/editorial on the finding. Maybe it will be published somewhere in the future? Perhaps also the reason why the study was featured in The Times...

Merged thread Am afraid this landmark study featured in the Times article is just the pilot study discussed here

I'm afraid they are referring to this study by the Griffith team, which does not seem lik a landmark study at all: Novel characterization of endogenous transient receptor potential melastatin 3 ion channels from Gulf War Illness participants 2024 Marshall-Gradisnik | Science for ME (s4me.info)

Scientists say soldiers suffering from mysterious symptoms since the 1991 war are likely to have been exposed to hazardous biological and chemical agents. Full text at: https://www.thetimes.com/uk/defence/article/cause-of-gulf-war-syndrome-identified-in-landmark-study-v585cltjx By Larisa Brown...

It seems that they mostly focus on medical students. So if they use something like the IOM report, Mayo review article, NICE guideline or just the Wikipedia page on ME/CFS it would likely be much better than what most medical students learn about ME/CFS (if they hear anything about it all).

Thanks for sharing. Maybe they can do an episode on ME/CFS? Did a quick search and noticed that none of the team members is an actual doctor or specialist. Zach Murphy, the CEO and guy in the videos is a physician assistant.

Does anyone know more about this @Dakota15 ?

Anyone else had a look at this?

This paper also reports: Post-exercise depression following submaximal and maximal isometric voluntary contraction - PubMed (nih.gov)

By the way: reference 19 is from the same research team (Samii et al. 1997. In this study they tested the amount of exercise needed to induce post-exercise depression in healthy people. Again, it seems that this refers to MEP done during the recovery phase, after exercise ended. The set-up is...

The graph reports the slope, so I assume this refers to the change in Dimitrov Index (DI) values, not the values themselves. So I don't think we know if ME/CFS patients had a higher DI at the beginning.

The description for figure 4.c (the one above) is also a bit confusing: For the graph on the slope of the Dimitrov index (Figure 4.B) they used: 'the first block (b1), the last block prior to fatigue onset (bn), and the first three blocks after fatigue onset (f1, f2, and f3)'. For Figure 4.C...

Had a look at the results on Motor Evoked Potential (MEP) which is an electrical signal generated in the muscles following stimulation of the brain.The authors tested this during the 30s rest blocks between exercises and describe the result as follows: Reference 19 is not about post-exercise...

Having had a quick look at the original paper, it seems that this measure (sometimes called FInsm5 or spectral fatigue index) is not used very often and was never validated in patient groups. I also haven't found a study that reports it like in the paper by Walitt and colleagues: 'the slope of...

This recent Japanese study also used the Dimitrov index, although they call it the spectral fatigue index (SFI). They tested 15 collegiate male athletes underwent three nonexplosive back squat tasks comprising low, medium, and high volumes. There was a significant relationship between Rate of...

This study tested the Dimitrov Index: "The log FInsm5 as a single parameter predictor accounted for 37% of the performance variance of changes in muscle power" but this was in 15 healthy participants who did 10 leg presses with 2 minutes in between. EMG spectral indices and muscle power fatigue...

So, if I understand correctly muscle fatigue manifests itself on electromyography (EMG) by an increase in amplitude and a shift towards lower frequencies. A bit like a cyclist tends to use a bigger gear and fewer resolutions when he is fatigued. Ratios between high and low frequency ranges have...