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In clinical trials, [the Shingrix vaccination] was shown to be 97% effective in preventing shingles in adults aged 50-69... Glad I got mine in my late 50s. Though did have to pay for it privately (thanks, Dad :hug:).

This whole approach looks more and more like just using technology for its own sake, to give the appearance of understanding and doing something. What the hell happened to people just learning to live with limitations at their own pace, without a whole lot of pointless performative...

Nice work. :thumbup: I can't see any problems with the basic hypothesis. It has the strengths of explanatory power, and parsimony, which I regard as critical in any good theory. Can you clarify what you mean by retardation in this context?

The virtues of humility, patience, prudence, courage, and hope mitigate the deprivations of CFS and promote well-being. Do they promote effective science?

Thus, as fatigability developed, the neuromuscular system experienced changes earlier than the actual behavior. While we found evidence for fatigability of central and peripheral origins, peripheral fatigue seems to occur first. If I am reading that correctly, it means that physiological...

And a lot more than money. Just as important, and sometimes more so, are power, status, reputation, face-saving, etc. Though a well above average income is always a powerful motivator too.

And the robust evidence for that (particularly for ME/CFS v. PTSD), including effect sizes and genetic commonalities, is...? Also, if it is "often" not always, then that alleged feature is not cardinal, and could just as easily be a misinterpretation, based on superficial similarities arising...

Pretty sure Glasziou was also heavily involved in the RACGP* guidelines on "incremental exercise' (aka GET) for ME/CFS, updated only last year. https://www.racgp.org.au/clinical-resources/clinical-guidelines/handi/handi-interventions/exercise/incremental-physical-activity-for-cfs-me...

Holistic Resonance Center :banghead:

Graded exercise is no longer routinely recommended. NICE explicitly recommended against it.

Seems like shameless lying and self-promotion is the main requirement for prominence in medicine these days.

Which is very close to the figure NICE reported. Hence any therapy recommended by the review has a high risk of harm.

highlights converging frameworks of dysregulated allostatic/stress responses in the context of predictive processing models of the brain. :rolleyes:

Psych diagnoses/attributions by clinicians usually tell us more about what is going on inside their heads then in their patients heads.

Thanks :thumbup:

Functional disorders share familial risk with internalizing disorders such as generalized anxiety disorder and depression, So, after the GWAS results the relevance to us of the 'functional' label is...? Functional disorders (FDs) such as fibromyalgia (FM), myalgic encephalomyelitis/chronic...

Could somebody post the full Google Drive link in that tweet.

She stresses psychotherapists’ limits: if biological and social needs were met, little would remain for her discipline to address. Grande gets it. This sounds like an article that would be worth translating in full.

I never said ME is FND, What about CFS? Is that FND? Just so we are clear.

And behave very much like a cult.