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  1. Sean

    Maeve Boothby O'Neill - articles about her life, death and inquest

    And yet the threat of these accusations and their appalling real world consequences continues on to this day. Their words are hollow, insulting, and cruel. And utterly gutless. It is beyond dispute that the profession, in cahoots with government, is completely incapable of facing up to the...
  2. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    It is arguable that the lack of genes known to be linked to depression and anxiety is evidence in favour of any depression and anxiety being secondary reactive consequences of primary physiopathology, combined with huge secondary losses caused by both the disease itself, and serious...
  3. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    Ask him about assessing treatment outcome by questionnaire, which is the preferred method of the psychosomatic/FND club. He might come to regret opening that can of worms.
  4. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    This. "...because they are never placed in such a situation." And they make damn sure of it.
  5. Sean

    Can Large Language Models (LLMs) like ChatGPT be used to produce useful information?

    I don't know how accurate those two AI statements above are (1, 2), but they seem to me clear and concise, which is always a big plus, if for no other reason than that makes it much easier to spot the limitations and flaws. It demonstrates what I have long thought is the main potential benefit...
  6. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    It is all marketing. His underlying belief about ME/CFS being a psycho-behavioural problem has not changed one bit, since his first comments on it in the formal literature back in the mid-1980s. Don't listen to what Wessely claims to believe, look at what he actually does, very consistently.
  7. Sean

    Criticisms of DecodeME in the media - and responses to the criticisms

    Wessely is just pulling his usual ex cathedra act. It is true because the Great Man said so. Accountability is coming, Sir Simon, and there is nothing you can do to stop it. And you thoroughly deserve it. You have been a deeply malign influence on this world, and have caused immense and...
  8. Sean

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    I strongly suspect that the undiagnosed or misdiagnosed rate, especially among the milder end of the spectrum, is going to be an important confounder in general. Nor would I be surprised if a decent chunk of that 'misdiagnosis' in particular was from wiser and more compassionate clinicians...
  9. Sean

    DecodeME in the media

    The only words I want to hear from that man, and his fellow travelers, are 'sorry', and 'I resign'. And at well above the average rate for the general population. The poorly understood illness, which is estimated to affect many millions of people worldwide, is associated with debilitating...
  10. Sean

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    So is an infection triggered neuro-immune condition a broadly correct characterisation of ME/CFS, based on these findings? Maybe it is identifying currently healthy people who have an increased genetic risk of getting ME/CFS. Would be interesting to follow that group for a few decades and see...
  11. Sean

    Preprint Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome, 2025, DecodeMe Collaboration

    Stronger associations would have been nice, and there is the issue of inconsistency across studies to be addressed. But otherwise a very welcome and important step forward, that should help focus research efforts on more productive possibilities. Thank you to all involved. :thumbup...
  12. Sean

    DecodeME blog: X marks the spot where ME/CFS biology can be discovered

    Thank you, @Simon M. Clear and informative as always. :thumbup: Any idea how expensive, and how much value there is in a full detailed gene map study? Or do we have enough now to start focusing down?
  13. Sean

    Design and validation of an energy level diary for fatigue management in patients with post-COVID syndrome, 2025, Balke et al.

    The whole energy/fatigue paradigm, and especially 'managing' it, has been a disaster. It has completely derailed understanding and treatment.
  14. Sean

    Financial burden of patients with post-acute COVID-19 syndrome, 2025, Scheel-Barteit et al

    PCS is a high subjective financial burden What does 'subjective' mean in this context? Personal?
  15. Sean

    Health Care Use Before Multiple Sclerosis Symptom Onset, 2025, Marta Ruiz-Algueró, MD, PhD et al

    Yes. The correct interpretation is that doctors send patients to psychiatrists, not that patients 'see' psychiatrists. Don't know about other countries, but here a patient can't just go to a psychiatrist. They have to be referred to them by another doctor (usually a GP/PCP).
  16. Sean

    Trial Report Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT 2025 Nielsen, Stone, Edwards et al

    Functional motor disorder often causes persistent disabling symptoms that are associated with high healthcare costs. In recent years, specialist physiotherapy, informed by an understanding of functional motor disorder, has emerged as a promising treatment, but there is an absence of evidence of...
  17. Sean

    Somatic symptom and related disorders: Guidance on assessment and management for paediatric health care providers 2025 Saunders et al

    They all do. They have a basic template including stuff like how common it is, how difficult it is, how much it costs the economy, how important the sales pitch is, blah blah blah.
  18. Sean

    Closed UK: DecodeME updates, was recruitment thread.

    Gets released at 0430 Thursday my time, and it's late Tuesday afternoon here. So two more for me.
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