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  1. Sean

    Trial Report Awe reduces depressive symptoms and improves well-being in a randomized-controlled clinical trial, 2025, Lopez et al

    Yes, being in awe at something does not mean that thing is good. A nuclear weapon going off is a truly awesome sight. But probably not of much help in improving mental health.
  2. Sean

    The Born Free Protocol

    “Independent Theoretical Biochemist” Translation: Unable to find employment in a reputable institute or program.
  3. Sean

    Review What is the effect of education on fatigue in adults with neurological conditions? A systematic review and meta-analysis 2025 Simpson et al

    Yes, all sensible right thinking people know that paper towels work best to stop the tide. [taps head]
  4. Sean

    Push to change ‘misogynistic’ name of one of the world’s most common surgeries

    Hysteria was only removed as an official medical diagnosis in 1980. It was finally recognised that it does not exist and is sexist. Nah. After a brief pause for the sake of appearance they just relabeled it as Functional Neurological Disorder. The concept never went away.
  5. Sean

    ME/CFS Research Chatbot

    It is not just the GIGO problem, AI thus far has not shown any great capacity to independently reason, including understanding methodology and context. At this point it is little more than a fancy collator and summariser. Still does not in any sense understand the actual content of the material...
  6. Sean

    Academic publishing: a discussion

    More than a little ironic that peer review was not peer reviewed before it became the entrenched wisdom. And not for a long time after it was either.
  7. Sean

    Australia: National Health and Medical Research Council (NHMRC): Development of ME/CFS guidelines

    By their co-authors shall ye know them. Sandler seems to be the BPS rep on the panel.
  8. Sean

    How should biological researchers present their results about ME/CFS to the media - discussion thread.

    More like they think it is anxiety about non-symptoms, about misinterpreting normal somatic signals and sensations (e.g. DOMS). Exactly. It is dishonest and underhanded in the extreme for the psychs to claim that being worried about a life-destroying change in health status, with no...
  9. Sean

    Preprint Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic..., 2025, Martins et al.

    His excuse for that will probably be along the lines of not wanting to inflame an already volatile situation. I mean, we wouldn't want the professor to face awkward impertinent questions from his victims about his role in creating that situation in the first place, would we.
  10. Sean

    How should biological researchers present their results about ME/CFS to the media - discussion thread.

    Yep. It might be disheartening and frustrating to have deal with the psycho-political stuff, but it has to be done. Also, from the paper: Expect wilful misinterpretations of that term. Something like 'exercise phobia' might have been better. ––––––––– Psychobehavioural is a better term than...
  11. Sean

    Preprint Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic..., 2025, Martins et al.

    His own website describes exactly how he wants his work on ME/CFS to be seen, and his bravery in standing up against the hordes of militant anti-psych patients. Let's just say that there are other, less selective and less flattering, interpretations of it...
  12. Sean

    Who is Simon Wessely?

    Don't know how long ago he wrote that.
  13. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    Not to mention whether or not patients looked down the barrel of that psychosomatic gun in a sufficiently manly manner. It's a nice compare and contrast. Leaving aside the question of how accurate that claim is, how is he reliably discriminating the critical issue of which causal pathway...
  14. Sean

    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    Phew, what a massive arsehole. :grumpy: I see he is an orthopaedic surgeon, which specialty has [checks notes] absolutely nothing to do with ME/CFS. On the good side, the fact that he is so open and abusive and extremist means he will have precisely zero room for excuses when the time for...
  15. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    re: BMI effects on ALP My single data point is that my ALP has remained in the same range independent of my BMI (which was ≈22-25 for the first 25 years of ME/CFS, then rising slowly to ≈28-30 over the 15 years or so since).
  16. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    I have persistently high ALP. It was first noted in my initial diagnostic workup for ME/CFS in 1989, and has been high every single time it was measured since then (including routine annual bloods).
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