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This is an important factor in general to control for in ME/CFS research, not just for ESR. I suspect we are going to see two different overall profiles: one during the initial stages, then a change to a different profile after that. I would need to check, but IIRC I had a low ESR early on...

Isometric exercises are excellent, for the rest of the population, but not for me any more. Pre-ME I used to score high in general fitness tests and exercise capacity. Suddenly I didn't and couldn't any more, at least not without sometimes extreme payback.

*As long as you ignore morbidity and mortality.

Adding a comma makes a lot more sense. ...and can result in a worsening of a constellation of symptoms, leading to extreme fatigue, cognitive impairment and flu-like symptoms within hours or days after exertion, lasting days to weeks.

Chronic fatigue syndrome (CFS) is a psychosomatic disorder characterized by persistent fatigue, primarily involving physical and mental exhaustion, with greater emphasis on the latter. So much wrong in so few words. That takes some skill.

Yes, the volume of a room is not determined by measuring its temperature.

I feel this one. All the way to the bone.

Also worth checking Librivox, which is the audio book equivalent of the Gutenberg sites. (i.e. All public domain sources only, so tends to be older stuff.) It is an entirely volunteer project, so the quality of both the reading and recording is variable, but there is some good stuff on there and...

after exertion lasting days to weeks. More like as little as minutes.

What else does it imply? Clinically significant is a minimum threshold value. Why bother even defining such a value if you are going to then ignore it? Sorry, I forgot. Psycho-behavioural studies don't have to follow standards, not even their own.

Made the second of my two donations. :thumbsup:

Useful to know.

Anything but 'client'. :grumpy:

Not to mention being honest about it.

:banghead::banghead::banghead: :mad::mad::mad:

Firefox has it. [EDIT: And Safari, in macOS.]

As Guenter himself noted, these diagnoses were not confirmed. How does pseudo-scientific shit like this keep getting approval and funding?

In real estate it is location, location, location. In psychosomatics it is rebrand, rebrand, rebrand.

As a result, behavioral and neuroimaging studies of FS have revealed a spectrum of structural, functional, genetic, and neuroinflammatory abnormalities in brain regions crucial for inhibition, executive control, emotion regulation, and sensorimotor processing. Doesn't sound functional to me.

Which is a nasty double-bind par excellence. It is exactly the sort of fundamental methodological error that psychs in particular should understand and do everything they can to avoid placing the patient in it. Yet they instead ruthlessly exploit it to cover up their ignorance, incompetence...