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Randomisation is just one of the means to control. A very important one, that should be used wherever possible. But not enough on its own. There still needs to be adequate blinding and/or objective outcome measures used as well.

Or award points for good one, none for a mediocre one, and negative points for a bad one.

Ministers have left the door open to a humiliating U-turn After an unnecessary, entirely self-inflicted, and long overdue humiliation. Good. Time they got some serious backlash against this endless naked cruelty against the sick, disabled, and poor. The fact that they thought it was a good...

There’s enormous subjectivity in diagnosis, Oh, the irony. Yep. No coincidence at all. Infinitely flexible, infinitely adaptable. The God of the Gaps in medicine. All because they cannot simply say: We don't know.

In my experience of this world 'radical overhaul/reform' almost always is a cover for cost & service cuts. Rarely ends well.

In my experience text-to-speech is very useful in shortish bursts, and I am grateful for it. But it is not so good for extended reads. It gets very drone like and relentless, almost oppressively at times, as it lacks the normal semi-random variations in tone and pace and rhythm found in...

As I have been saying for years, psychosomatics has become a cult, and like all cults they are openly hostile to critics and criticism, and will actively reject and suppress all criticism, especially informed accurate criticism. And the more informed and accurate and persistent the criticism...

CONCLUSIONS These findings suggest that FND is characterized by dysregulated bioenergetics and increased vulnerability to oxidative stress. Understanding NMetNet in FND offers novel insights into the disorder’s neurobiology, with implications for therapeutic interventions to restore energy...

I have not got many emails from them, mostly just ones thanking me for a donation, best I can recall. But I am still getting the glossy paper mail stuff, despite writing to them a while back and asking them not to send them, which they acknowledged and said they would stop doing. And they did...

Straw man.

While I am generally in favour of locally managed service delivery, there still needs to be some broader national oversight to maintain standards and ensure that no local organisation goes too far off the rails.

I am fairly confident that when we do understand ME/CFS properly we are going to find that, for many patients at least, it has a prodromal phase, possibly quite a long one in some cases, up to decades, before it develops into the full blown syndrome. Also that the prodromal phase is going to...

Cochrane are barely even pretending, are they. Can Cochrane be sued over this (for negligence and harm, maybe misleading advertising as the definitive authoritative source of clinical reviews)? Particularly in the UK.

That was my first thought.

Another victim of Prof Crawley's glorious career. :grumpy:

a prevalence of at least one symptom of PEM WTF does that even mean? o_O

catastroenterologists ?

However, this is just not happening and very little progress has been made since publication of the new NICE guideline of ME/CFS in October 2021 – apart from the removal of graded exercise treatment from these services. Well, since the removal of the term 'graded exercise therapy' and the...

These services offer physical, cognitive, and psychological assessment, and, where appropriate, refer patients onto existing services for treatment and rehabilitation. SOS Same Old Shit.

"Do we have a single answer? Not as of yet, and most likely, perhaps we'll have more than one answer," he said. FFS, just say 'we don't know, we don't have any good answers at this stage', and leave it at that. Stop prejudicing the process when it has barely got started.