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  1. Sean

    2025: The 2019/24 Cochrane Larun review Exercise Therapy for CFS - including IAG, campaign, petition, comments and articles

    Yes, interesting double standard: Subjective self-report from patients is adequate to claim therapeutic benefit, including in the absence of support from objective measures, while also being insufficient to warn of harm, even though harms require a much lower threshold to trigger concern. Maybe...
  2. Sean

    Effectiveness of a personalised self-management intervention for people living with long covid (Listen trial), 2025, Jones et al

    The LISTEN trial illustrates the need and value of further research in to personalised treatments delivered by a multidisciplinary team in community settings and people's homes. It does no such thing, you liars. Just in case anybody doesn't know, in the south of the USA, at least, that is an...
  3. Sean

    Exertional Exhaustion [PEM] Evaluated by the Effects of Exercise on [CSF] Metabolomics–Lipidomics and Serine Pathway in [ME/CFS], 2025, Baraniuk

    Exercise led to consumption of lipids in ME/CFS and controls while metabolites were consumed in ME/CFS but generated in controls. Interesting, if it holds up.
  4. Sean

    NHS: GP surgeries; privatisation; physician associates

    One serious indicator of a failing state is their inability to train up, and retain, their own citizens for technical positions in particular. The same problem is happening here is Australia. The health system is being flooded by people from overseas. Not just the health system, all sorts of...
  5. Sean

    Mind and Body in the Guardian again

    Even more. Because it is so much more unfalsifiable, and hence much harder to refute. Psychologisers have an endless supply of arbitrary re-framings to play whack-a-mole and use to hang onto their power. The software/hardware analogy simply does not apply to wetware (biology). They are...
  6. Sean

    Clare Gerada: influence on UK medical practice and ME/CFS management

    The golden age of psycho-tyranny has begun.
  7. Sean

    Review Beyond physical exhaustion: Understanding overtraining syndrome through the lens of molecular mechanisms and clinical manifestation, 2025, Fiala et al

    The phenomenon of over training in otherwise healthy people strongly suggests to me that ME/CFS patients are dealing with unrelenting pathological physical demands that produce results which have a lot in common with extreme over training. The difference being that the cause of over training is...
  8. Sean

    Understanding Chronic Fatigue Syndrome – Workshop with Dr Bruno Silva [North Staffordshire Combined Healthcare NHS Trust]

    Or, there is simply a sampling/reporting bias in those who persist in trying to figure out what the problem is, as opposed to those who, for whatever reason, do not and just try to survive it all. He got this very critical point right.
  9. Sean

    Shingles vaccines, chickenpox, Shingrix

    Reaching into the memory banks on this one, but I think that protective effect applies mainly to females, less so for males.
  10. Sean

    Review Effects of traditional Chinese mind-body exercises for patients with chronic fatigue syndrome: A systematic review and meta-analysis 2023 Kong et al

    Tai-Chi seems to me among the most optimal and safe forms of general exercise, and I did give it a good go about 20 years back. But its effects on my ME/CFS was no different than any other form of exercise or physical activity, however gentle and carefully titrated. Also tried yoga 35 years...
  11. Sean

    The effects of exercise on dynamic sleep morphology in healthy controls and patients with chronic fatigue syndrome, 2013, Kishi et al

    I have had that at various times. Especially early on, not so much any more. Might be in part because of getting old (early 60s).
  12. Sean

    Review Dietary Supplementation for Fatigue Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systematic Review, 2025, Dorczok

    Conclusions: Though some DSs showed potential in reducing fatigue in ME/CFS, methodological limitations and inconsistent results hinder definitive conclusions. Take note, psycho-behaviouralists.
  13. Sean

    News from Aotearoa/New Zealand and the Pacific Islands

    :facepalm::grumpy:
  14. Sean

    Brief Outpatient Rehabilitation Program for Post-COVID-19 Condition, Nerli et al, 2024 - with comment from T. Chalder

    Propaganda works. And sometimes the more blatant and shameless it is, the better it works.
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