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Yes. Unfortunately, I don't have a lot of examples off the top of my head. But for example, they don't really know how SSRIs work for depression (if they actually work at all and it's not placebo). Wikipedia Another example is general anesthesia:

You could just see that it works when patients take it for an unrelated reason. That appears to be the basis of all the B cell depletion drug trials in Norway. Cancer patients took chemo drugs and their ME/CFS got better. Wikipedia says the tree that contains a similar chemical to Aspirin was...

T Cell Dysregulation in Long-COVID: Immune Profiling and the Potential Role of Short-chain Fatty Acids in Modulating T-cell Functionality Zhihua Wu, Kieran Tuohy, Frederique Ponchel Abstract Long-COVID (LC) affects over 400 million individuals globally and is characterised by persistent...

@elimrogers Thank you for joining and offering to share your paper. Unfortunately, it's really hard for me to follow these types of historical/sociological topics, so I'm not sure how much I can personally understand or contribute. I'm sorry that comments on this forum have been hurtful. But...

Can you clarify what is offensive? She can't write about ME/CFS because she doesn't have it? I can't follow what your criticism of the piece is.

There are some resources for learning about the immune system here: https://www.s4me.info/threads/learning-about-the-immune-system.43381/ And Sasha talks about that book here: https://www.s4me.info/threads/visual-media-for-learning-biology-medicine.39380/post-611356

Quoting a post about another immune system resource, the book 'Immune' from Kurzgesagt, from the thread, Visual media for learning biology/medicine:

Over £1000 in a day. Very nice work @Joan Crawford.

I always thought of it as some side effect or other circumstance occurring that makes participants more certain what group they're in, unrelated to the outcome of interest. For example, if a patient gets a characteristic rash that is only known to happen with the active drug, they're no longer...

Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study Taneli Lehto, Teemu Zetterman, Dominique Gagnon, Ritva Markkula, Jari Arokoski, Eija Kalso & Juha E. Peltonen [Line breaks added] Purpose We studied muscle and brain oxygenation during...

No, not that I can see.

Now published: Web | PDF Only minor formatting changes to abstract from above version.

Previous paper: Development and evaluation of blood-based prognostic biomarkers for COVID disease outcomes using EpiSwitch 3-dimensional genomic regulatory immuno-genetic profiling, 2024, Hunter et al Thread for press release about that paper: Oxford BioDynamics shares gain on Covid test...

If I understood it correctly, this study looked at absolute count of CD16+CD56+ cells at baseline in the blood, like the ME/CFS study, and found no correlation with response to daratumumab: Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory...

For this one, frequency of total NK cells wasn't different between multiple myeloma responders and nonresponders in either bone marrow or blood. What was different was higher proportion of CD16+ NK cells and lower TIM-3+ NK and HLA-DR+ NK cells in the bone marrow in responders. I'm not sure if...

It'd would be good to know how correct this is about, for example, spleen plasma cells being mostly non-specific. That's just what I remember from an intro to immunology textbook. Maybe high IGHV3-30 from the other studies might also point to overly high levels of non-specific innate-like...

Maybe, but if blood count was a good proxy for bone marrow count, I'd expect studies showing that blood NK count in multiple myeloma correlates with improvement from dara, but I haven't seen such a study. I don't think it's impossible. Maybe the body can deal with the antibodies from, say, 1000...

I think also: 1. Faulty T cells being the problem 2. Faulty NK cells being the problem 3. Some other cell that expresses CD38 being the problem. I don't think they say anything about exact levels of protective antibodies, just that they're still at protective levels at 12 months, so maybe...

The association of fatigue and pain with cognitive test performance in patients with myalgic encephalomyelitis/chronic fatigue syndrome Joukje M. Oosterman, Marieke van der Schaaf, Willemien P.E. de Kleijn, Tanja A. Kuut, Inti A. Brazil, Hans Knoop Highlights • Fatigue severity was the...

Preliminary evaluation of a cognitive rehabilitation intervention for post-COVID-19 cognitive impairment: A pilot randomized controlled trial Jacqueline H. Becker, Eric Watson, Nadia Zubair, Fernando Carnavali, Emilia Bagiella, David Reich, Juan P. Wisnivesky Background: Despite the profound...