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Good point about the beta blocker. Heart rate wouldn't be considered a direct measure of exertion, it would just be a proxy marker. If you take a beta blocker to decrease the correlation between exertion and heart rate, then it wouldn't act as a good proxy anymore. Any studies that used this...

Yes, it's very simple: mild people's hearts would beat more times throughout the day because they are participating in more exertion than severe people. Only slightly more complicated when considering only those heart beats that are in excess of resting heart beats to normalize between people.

Could you give an example(s) of what you mean? For example, in the dara trial, I'm suggesting that average heart rate might have better captured how much more people were actually doing, versus average step count. And insofar as we can at least get a rough idea of a person's severity from...

I think the disconnect might be that you're talking about a simple difference between resting heart rate and maximum heart rate during the day. I'm talking about averages. If you get your HR up to 150 bpm for a minute, that won't increase your average bpm as much as increasing to 90 bpm for an...

I'm wondering whether average heart rate, acting as a measure of total exertion, might be a good measure of ME/CFS severity. Step count and upright time don't really disambiguate between type of activity performed. For example, slow walking, normal walking, and running all count the same when...

Association of Long COVID-Related inflammatory Processes in the Musculoskeletal System: 12-Month Longitudinal Cohort Feasibility Study Background A subset of individuals develops persistent symptoms following SARS-CoV-2 infection, including musculoskeletal (MSK) manifestations, a condition...

Differential Characteristics and Comparison Between Long-COVID Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Abstract Long-COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome are disabling diseases characterised by ongoing fatigue, post-exertional malaise...

Reduced prepulse inhibition associated with fibromyalgia in two studies. It might be good to test this in ME/CFS. Alterations in excitatory and inhibitory brainstem interneuronal circuits in fibromyalgia: Evidence of brainstem dysfunction, 2014, Kofler et al Web | DOI | Clinical...

It seems to me like "10 years" refers to the span between the 1998 study and this study:

It took 16 years to analyze and publish?

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Yeah it looks like being diagnosed with fibromyalgia is associated with a decrease in PPI, with a comorbidity of FMD making little difference. More generally, higher scores on the Fibromyalgia Severity Scale, no matter what your diagnosis, correspond to lower PPI. And people with FMD without...

Just eyeballing, it looks like the FMD+FM and FM groups are pretty much overlapping.

Article about this thread's paper: Retraction Watch: 'Springer Nature flags paper with fabricated reference to article (not) written by our cofounder' Also, 39 comments currently on PubPeer pointing out issues with the paper: https://pubpeer.com/publications/5CC4D1FB2B21DBB3D50E3DFDAE2543

My attempt to parse this: The text I quoted indicates that the middle part of the table (Indication of post-exertional malaise) shows how many people in each group had PEM at 3 months. This suggests to me that the part below it (Indication of ME and/or CFS diagnosis) is similar, but instead...

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Cognitive impairment, depression, and fatigue in post-COVID and post-vaccination syndrome: a large-scale cross-sectional study [Line breaks added] Background Persistent cognitive difficulties are among the most prevalent symptoms observed after COVID-19. This study examined the...

Evidence for a severe cognitive subgroup in a comprehensive neuropsychological Post-COVID-19 syndrome classification [Line breaks added] Abstract Approximately 7% of adults develop Post-COVID-19 syndrome (PCS). Cognitive impairment is common, but its profile in PCS is not well defined and...

The Guardian: 'Ultra-processed food linked to harm in every major human organ, study finds' "Evidence reviewed by 43 of the world’s leading experts suggests that diets high in UPF are linked to overeating, poor nutritional quality and higher exposure to harmful chemicals and additives. A...

Ultra-processed foods and human health: the main thesis and the evidence Summary This first paper in a three-part Lancet Series combines narrative and systematic reviews with original analyses and meta-analyses to assess three hypotheses concerning a dietary pattern based on ultra-processed...