type i interferon

Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity Pujantell, Maria; Altfeld, Marcus Abstract The immune system protects us from pathogens, such as viruses. Antiviral immune mechanisms aim to limit viral replication, and must maintain immunological...

Increased proportion of CD56bright natural killer cells in active and inactive systemic lupus erythematosus Abstract Summary Natural killer (NK) cells belong to the innate immune system but can also affect adaptive immune reactions. This immune regulatory function is often ascribed to the...

Mitochondria-localised ZNFX1 functions as a dsRNA sensor to initiate antiviral responses through MAVS Abstract In the past two decades, emerging studies have suggested that DExD/H box helicases belonging to helicase superfamily 2 (SF2) play essential roles in antiviral innate immunity...

Exaggerated IFN-I Response in Long COVID PBMCs Following Exposure to Viral Mimics Purpose Long COVID (LC) is a long-term debilitating disease of which the exact pathophysiology is unknown. A dysregulated immune response resulting in hyperresponsive immune cells is hypothesized as a key...

Immune transcriptomic changes in Australian Gulf War veterans Eaton-Fitch, Natalie; Sasso, Etianne Martini; Marshall-Gradisnik, Sonya [Line breaks added] Background Gulf War Illness (GWI) is a chronic multisystemic illness found in one-third of Gulf War Veterans. The aetiology of GWI is...

An emerging role for calcium signalling in innate and autoimmunity via the cGAS-STING axis Mathavarajah, Sabateeshan; Salsman, Jayme; Dellaire, Graham Abstract Type I interferons are effector cytokines essential for the regulation of the innate immunity. A key effector of the type I interferon...

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis Ji T, Zhao T, Long S, Wei C, Cheng D, Chen J, Kuang L Abstract The inflammatory cytokine storm is a hallmark of sepsis and is highly correlated with organ injury. Therefore, inhibiting...

Posting several links exploring temporal dynamics between interferon, autoantibodies, and autoimmune diseases (primarily lupus). (Review) Emerging concepts of type I interferons in SLE pathogenesis and therapy Note: SLE = systemic lupus erythematosus Links to references are active in the...

TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis Although anti-tumor necrosis factor (TNF) agents are highly effective in the treatment of psoriasis, 2–5% of treated patients develop psoriasis-like skin lesions called paradoxical...