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Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel

Discussion in 'Long Covid news' started by Mij, Jan 17, 2022.

  1. Mij

    Mij Senior Member (Voting Rights)

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    8,204
    Association between vaccination status and reported incidence of post-acute COVID-19 symptoms in Israel: a cross-sectional study of patients tested between March 2020 and November 2021
    Paul Kuodi, Yanay Gorelik et al

    Abstract
    Background: Long COVID is a post-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection syndrome characterised by not recovering for several weeks or months following the acute episode. The effectiveness of COVID-19 vaccines against long-term symptoms of COVID-19 is not well understood. We determined whether vaccination was associated with the incidence of reporting long-term symptoms post-SARS-CoV-2 infection.

    Methods: We invited individuals who were PCR tested for SARS-CoV-2 infection at participating hospitals between March 2020-November 2021 to fill an online questionnaire that included baseline demographics, details of their acute episode and information about symptoms they were currently experiencing.
    Using binomial regression, we compared vaccinated individuals with those unvaccinated and those uninfected in terms of self-reported symptoms post-acute infection.

    Results: We included 951 infected and 2437 uninfected individuals. Of the infected, 637(67%) were vaccinated. The most commonly reported symptoms were; fatigue (22%), headache (20%), weakness (13%), and persistent muscle pain (10%).

    After adjusting for follow-up time and baseline symptoms, those who received two doses less likely than unvaccinated individuals to report any of these symptoms by 64%, 54%, 57%, and 68% respectively, (Risk ratios 0.36, 0.46, 0.43, 0.32, p<0.04 in the listed sequence). Those who received two doses were no more likely to report any of these symptoms than individuals reporting no previous SARS-CoV-2 infection.

    Conclusions: Vaccination with at least two doses of COVID-19 vaccine was associated with a substantial decrease in reporting the most common post-acute COVID-19 symptoms, bringing it back to baseline. Our results suggest that, in addition to reducing the risk of acute illness, COVID-19 vaccination may have a protective effect against long COVID.

    https://www.medrxiv.org/content/10.1101/2022.01.05.22268800v2

    Covid cases who got 2 vaccine doses reporting much less long-Covid symptoms than unvaccinated-they're reporting no more than uninfected people- suggesting vaccination brings these symptoms back to baseline.
     
    mango, Simon M, Sly Saint and 12 others like this.
  2. Mij

    Mij Senior Member (Voting Rights)

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    COVID.JPG
     
    Simon M, Tia, Ariel and 6 others like this.
  3. Peter Trewhitt

    Peter Trewhitt Senior Member (Voting Rights)

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    Potentially very reassuring for those of us here in the UK where we have a government that increasingly by relying on herd immunity through vaccination and allowing the disease to spread almost unrestrained had made an enormous gamble about potential levels of Long Covid.
     
    Sarah94, Mithriel, Tia and 7 others like this.
  4. JemPD

    JemPD Senior Member (Voting Rights)

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    So full vaccination reduces risk of long covid according to this study?
     
    Tia, Kitty, Wonko and 3 others like this.
  5. rvallee

    rvallee Senior Member (Voting Rights)

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    Location:
    Canada
    With the caveat of a control cohort in which 18% of the population reports fatigue. Without a value on those it's hard to say how valid this is. For sure 18% of the population does not have disabling fatigue, but it would be interesting to verify whether/how vaccination somehow reduces that number by almost 40%. And of course as usual PEM is far more significant than fatigue, which probably has more different meanings than the word set. But they don't ask about that, or have any depth to the values.

    Most of the official research only uses binary, presence of symptoms or not. It's lacking most of the depth that the patient-led research did, so far still the best by a wide margin.

    Also some of this could be recency, with the 3rd dose being more recent. I don't think there's much to conclude here yet.
     
  6. Creekside

    Creekside Senior Member (Voting Rights)

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    How does one factor in the fact that people who get 2 doses have different mindsets than those who get one dose, who have different mindsets than those who haven't gotten vaccinated? Strong belief in the protection of 2 doses is likely to make those people underreport any symptoms.
     
    Sarah94 and Peter Trewhitt like this.
  7. Sarah94

    Sarah94 Senior Member (Voting Rights)

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    3,601
    Location:
    UK
    Yes, although if newer variants like Omicron have a significant level of vaccine escape, then that protection against long covid may not hold.
     
    Simon M and Peter Trewhitt like this.

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