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Open Australia: Griffith Uni: ION CHANNEL DYSFUNCTION IN ME/CFS

Discussion in 'Recruitment into current ME/CFS research studies' started by Tom Kindlon, Jul 18, 2022.

  1. Tom Kindlon

    Tom Kindlon Senior Member (Voting Rights)

    Messages:
    2,199
  2. John Mac

    John Mac Senior Member (Voting Rights)

    Messages:
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    This group of researchers have been implicating TRP ion channels for several years now, has anybody
    replicated their findings?
    If it was a valid finding surely it would have been validated by now.
     
  3. Andy

    Andy Committee Member

    Messages:
    21,810
    Location:
    Hampshire, UK
    From the linked flyer

    "This project aims to investigate the role of ion channel dysfunction in ME/CFS and PVS patients as potential diagnostic and therapeutic targets.

    We are recruiting the following participants:

    • ME/CFS group: participants who have received a diagnosis of ME/CFS (where diagnosis was made using the CCC 2003 or ICC 2011 definitions).

    • PVS group: participants reporting chronic symptoms following a known viral infection, but have not received a diagnosis of ME/CFS nor other medical condition explaining the symptoms.

    • Control group: participants who report no health concerns.


    The inclusion criteria are as follows:

    • Australian residents aged 18 to 65 years old

    • Non-smoker

    • No current diagnosis of serious chronic illness, e.g. autoimmune, cancer, cardiovascular, diabetes or primary psychiatric diseases

    • Not pregnant or breastfeeding


    This study involves:

    • Donations of 84ml of blood

    • Completion of an online questionnaire"
     
  4. CRG

    CRG Senior Member (Voting Rights)

    Messages:
    1,857
    Location:
    UK
    I don't think there's anything 'invalid' in what the Griffiths Uni team are doing - it's the way lots of chemical physiology has progressed, teasing apart one element at a time. With TRPICs there's a range of related functions, all of which may operate in different ways https://en.wikipedia.org/wiki/Transient_receptor_potential_channel#Families Certainly it's a labourious way of going about things which is why a lot is riding on Decode ME as possible means to shortcut what is otherwise a long hard slog.
     
    Hutan, Sean, merylg and 3 others like this.
  5. Kitty

    Kitty Senior Member (Voting Rights)

    Messages:
    5,051
    Location:
    UK
    It sounds like an interesting possibility to rule in or out—good luck to them. :thumbsup: It'd be great to get a reasonably clear result in an ME research project, even if it's a negative that advances our knowledge of where not to look.
     
    Trish, Hutan, merylg and 3 others like this.
  6. alex3619

    alex3619 Senior Member (Voting Rights)

    Messages:
    2,129
    Which saves resources and lets them go to other projects. Most of the research is advance an idea, test it till it breaks, find a new idea. Eventually one wont break.
     
    MeSci, Binkie4, Wonko and 5 others like this.

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