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Exercise Intolerance in Post-Acute Sequelae of COVID-19 and the Value of Cardiopulmonary Exercise Testing- a Mini-Review, 2022, Aparisi et al

Discussion in 'Long Covid research' started by Andy, Aug 9, 2022.

  1. Andy

    Andy Committee Member

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    Hampshire, UK
    Coronavirus disease (COVID-19) is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with systemic organ damage in the most severe forms. Long-term complications of SARS-CoV-2 appear to be restricted to severe presentations of COVID-19, but many patients with persistent symptoms have never been hospitalized. Post-acute sequelae of COVID-19 (PASC) represents a heterogeneous group of symptoms characterized by cardiovascular, general, respiratory, and neuropsychiatric sequelae. The pace of evidence acquisition with PASC has been rapid, but the mechanisms behind it are complex and not yet fully understood. In particular, exercise intolerance shares some features with other classic respiratory and cardiac disorders. However, cardiopulmonary exercise testing (CPET) provides a comprehensive assessment and can unmask the pathophysiological mechanism behind exercise intolerance in gray-zone PASC. This mini-review explores the utility of CPET and aims to provide a comprehensive assessment of PASC by summarizing the current evidence.

    Open access, https://www.frontiersin.org/articles/10.3389/fmed.2022.924819/full
     
    Sean, RedFox, Peter Trewhitt and 2 others like this.
  2. RedFox

    RedFox Senior Member (Voting Rights)

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    No mention of 2-day CPETs or PEM?
     
    Sean, Peter Trewhitt and bobbler like this.
  3. bobbler

    bobbler Senior Member (Voting Rights)

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    With the various terms that are getting pushed - is this PASC term including people who had acute severe covid (in intensive care) and are 'recovering from that slowly but surely' lumped in with the long-covid, where they were never in hospital originally?

    I'm very concerned from what I've seen over the years that the two aren't being separated and that the specialists appropriate for each area haven't been confirmed so when you get this it invariably tends to be a lung specialist calling anything that doesn't involve the lung rehab+anxiety type stuff (ie 'the bit for another dept') without feeling the need for that to be unpacked and have methodology appropriate to the separate type of condition. Particularly given those who were in intensive care under horrid conditions for so long will need the opposite to long covid as they will have had deconditioning from being sedated, ventilated and PTSD from all that life-threatening and thoroughly unpleasant experience + drugs.
     
    Sean, Snow Leopard and Peter Trewhitt like this.
  4. RedFox

    RedFox Senior Member (Voting Rights)

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    1,244
    Location:
    Pennsylvania
    This is how I see PASC and Long Covid generally used in practice: They're two terms for the same thing, but PASC is more formal and used in research papers, and Long Covid used by patients and media. They're both umbrella terms for any health problem caused by Covid-19, thus they include diverse symptoms and pathology.
     

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