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Gastrointestinal neoplasia: carcinogenic interaction between bile acids and Helicobacter pylori in the stomach, 2022, Madeline Alizadeh

Discussion in 'Other health news and research' started by Mij, May 20, 2022.

  1. Mij

    Mij Senior Member (Voting Rights)

    Messages:
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    Abstract

    Bile acids modulate cell functions in health and disease, however, the mechanisms underlying their actions on neoplastic cells in the gastrointestinal (GI) tract remain largely unknown. In this issue of the JCI, Noto et al. comprehensively analyzed how interactions between Helicobacter pylori infection, iron deficiency, and bile acids modulate gastric inflammation and carcinogenesis. The investigators used sophisticated models, including INS-GAS mice with elevated serum gastrin and gastric acid secretion, in which H. pylori infection mimics human disease progression, to show that selected bile acids potentiated the carcinogenic effects of H. pylori infection and iron depletion. This elegant work has broad translational implications for microbe-associated GI neoplasia. Importantly, bile acid sequestration robustly attenuated the combined effects of H. pylori infection and iron depletion on gastric inflammation and cancer.

    https://www.jci.org/articles/view/160194
     
    Peter Trewhitt, alktipping and Amw66 like this.

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