Announcement From Millions Missing Canada Research Results Released: qEEG Assessments for ME Volunteers From Laurentian University During the summer of 2018, researchers from Laurentian University Neuroscience Department led by Andrew Pellegrini, visited 45 ME patients in their homes in Ontario. The purpose was to collect Quantitative Electroencephalographic (qEEG) data to investigate changes in brain functioning associated with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS). The reports for all 45 of the volunteers in the study have been completed and will be sent out over the next few days. Every member of the study showed statistically significant brain anomalies compared to healthy controls on Quantitative Electroencephalography (qEEG) related to ME/CFS. The reports are written so as to be primarily addressed to the physicians of each volunteer in hopes that the qEEG findings can be followed up with further testing as recommended for the benefit of the individual patients, and to help increase general medical understanding of ME based on hard neurological evidence. Most importantly, Dr. Sonia Neubauer MD, who's lab in Chile generated the modern SPECT maps used by Dr. Hyde has graciously agreed to have her contact information included in the reports. She is willing and available to do the same work she did for Dr. Hyde and his patients for each member of the study. While qEEG has proven useful, SPECT still represents the gold standard for showing brain dysfunction in ME. While Andrew had hoped to secure some method of funding as there is a fee associated with this analysis, unfortunately the cost will have to be borne by the individuals. This is also a medical test that will require a cooperative physician to make the referral and work with Dr. Neubauer. Given that many of the volunteers are clustered close together in Toronto and Ottawa perhaps the same physicians may see enough individuals with reports from the study to be open to this approach which is both somewhat unconventional and at the same time scientifically sound. Therefore, volunteers choosing to share their reports with their physicians should also include a copy of Andrew’s thesis document showing validation of Dr. Hyde's findings, as well as the technical details of how the study was conducted. A PDF copy of Dr. Hyde's 1992 text book (which is now freely available on his website) will also be attached as a reference material for physicians. While nearly 30 years old, the SPECT images shown in colour at the front clearly show that PEM is characterized by a dramatic worsening of cerebral blood perfusion above and beyond the pathological baseline. Modern researchers are still working to define PEM (Post Exertional Malaise) and Andrew believes that Dr. Hyde's findings are of essential importance even though they have not, as yet, been widely recognized. Andrew writes in his email to us, “This project has been one of the most interesting and rewarding experiences of my life and I am proud to be able to offer this small service to the ME/CFS community.” With our deepest thanks to Andrew for his dedication to this project and his commitment to the community. Congratulations Andrew on completing this milestone in your research. We wish you good health and much success in the future. Questions concerning your individual reports can be directed to Andrew. For those who want to know the backstory, the complete past history can be seen at: https://bit.ly/3hFD1G9 Andrew’s thesis, ‘Quantitative Electroencephalographic Assessment of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome: Support for a Novel Diagnostic Protocol’, by Andrew Pellegrini can be found at: http://bit.ly/2kn1LM5 The textbook, ‘The Clinical and Scientific Basis of Myalgic Encephalomyelitis Chronic Fatigue Syndrome’ by Bryon Hyde, Jay Goldstein and Paul Levine is free to download at the following link. https://www.nightingale.ca/publications Dr. Hyde’s new book ‘Understanding Myalgic Encephalomyelitis’ and other publications can be ordered at this link. https://www.nightingale.ca/publications A preview of Dr. Hyde’s new book ‘Understanding Myalgic Encephalomyelitis’ can be viewed or downloaded from the Nightingale Research Foundation at: https://www.nightingale.ca/ The ‘Definition of Myalgic Encephalomyelitis is available in four languages, English, French, Norwegian and Danish. It can be viewed or downloaded here: https://www.nightingale.ca/understanding-m-e Description of Attached Images: Figure 9 The Left Temporal Lobe: The aggregate of 45 ME brains is shown on the left, compared with NRF SPECT maps of individuals on the right. The same left temporal hypoperfusion pattern shown here has been demonstrated by Dr. Mena and colleagues in 13/13 children with ME/CFS (Goldberg et al., 2011). Figure 12 The Right Temporal Lobe: Regions of hyper and hypo-perfusion in the frontal, temporal and occipital cortices in this individual’s SPECT approximately cover the inferior half of the right hemisphere. Likewise, the aggregate of 45 brains, shown on the left, includes approximately the same area.