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Personal history of autoimmune disease and other medical conditions and risk of myelodysplastic syndromes, 2022, Linabery et al.

Discussion in 'ME/CFS research' started by Dolphin, Jan 8, 2022.

  1. Dolphin

    Dolphin Senior Member (Voting Rights)

    Messages:
    4,990
    I'm not sure whether chronic fatigue syndrome is well-defined or not

    https://www.sciencedirect.com/science/article/abs/pii/S1877782121002071

    Cancer Epidemiology
    Volume 76, February 2022, 102090

    Personal history of autoimmune disease and other medical conditions and risk of myelodysplastic syndromes
    Amy M.Linabery
    Michelle A.Roesler
    Michael Richardson
    Erica D.Warlick
    Phuong L.Nguyen
    Adina M.Cioc
    Jenny N.Poynter

    https://doi.org/10.1016/j.canep.2021.102090

    Highlights



    MDS cases were significantly more likely to have a previous diagnosis of autoimmune disease when compared with controls.


    Previous diagnosis with autoimmune disease did not impact overall survival following an MDS diagnosis.


    MDS cases were also more likely to report coronary heart disease and chronic fatigue syndrome than controls.



    Abstract
    Background
    Autoimmune diseases and hematopoietic malignancies are known to cluster within individuals, suggesting intertwined etiologies. A limited number of studies have evaluated pre-existing medical conditions as risk factors for myelodysplastic syndromes (MDS). We evaluated associations between autoimmune disease and other medical conditions and risk of MDS.

    Methods
    Cases were identified through the Minnesota Cancer Reporting System. Controls were identified through the Minnesota State driver’s license/identification card list. History of autoimmune disease and other medical conditions was based on self-report; proxy interviews were not conducted. Unconditional logistic regression was used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CI).

    Results
    We included 395 cases and 694 controls. Cases were significantly more likely to report a diagnosis of any autoimmune disease when compared with controls (aOR=1.41, 95% CI: 1.05–1.89) after adjustment for age, sex, education, NSAID use, exposure to benzene and body mass index. When we evaluated specific autoimmune conditions, a statistically significant association was observed for hypothyroidism (aOR=2.16, 95% CI: 1.39–3.34) and odds ratios were elevated for inflammatory bowel disease (aOR=1.75) and systemic lupus erythematosus (SLE; aOR=3.65), although these associations did not reach statistical significance. Presence of an autoimmune condition did not impact overall survival (p = 0.91).

    Conclusion
    Our results validate previous findings of an association between autoimmune disease and MDS. Further studies are required to determine whether this association is due to shared etiology, treatment for autoimmune diseases, or altered immune surveillance or bone marrow damage caused by the autoimmune condition.

    Keywords
    Myelodysplastic syndrome
    Autoimmune disease
    Chronic immune stimulation
    Risk factor
     
    Sean, Ash and Peter Trewhitt like this.
  2. rvallee

    rvallee Senior Member (Voting Rights)

    Messages:
    12,299
    Location:
    Canada
    Seems more like early misdiagnoses. Which are clearly very common. It would be great if medical specialties actually cared about "their patients" being misdiagnosed. It's not going to improve by magic, though. Or by doing more of the thing that leads to massive systemic misdiagnosis, as this particular problem is often presented as the solution to the problem. Somehow.

    Or nothing could be done about it. As is tradition. Waiting until problems get worse is another way to do things. Not a good one, but it is one.
     
    Sean and alktipping like this.

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