Preprint Spironolactone for ME/CFS in a Patient Homozygous for rs5522 (I180V): A Case Report, 2026, Donnellan et al

DonnellanP said:
You are right. I was wrong. I apologize for the confusion. I got the SNP orientation wrong initially It is C to T. I posted the NIH link. tHe clinical benefit remains unchanged.
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@DonnellanP, are you planning to correct the case report now that you know it is incorrect? I see that you are still citing the case report as evidence and reporting the incorrect interpretation on Bluesky. From May 19:
Yes, T/T for rs5522 means you have two copies of the variant coding for the valine amino acid that drives MR overactivity. Please read the case report.
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Edit: Your website that you linked also still gives incorrect information, saying T leads to valine.
 
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Yes, it is the major variant. This does not mean that is does not cause ME/CFS, it means it drives ME/CFS, and MS and the neuro inflammation that contributes to MS and Parkinson's and creates a rich inflammatory environment where cancer can grow and hide.

Separate diseases, but all stemming from chronic inflammation. The pathway that it takes in each carrier will be determined by biology and environment. For us, the energy production system shut down and went into hibernation. For someone else, their energy system might have compensated, but the chronic inflammatory environment might attack the myelin leading to a dx of MS.

I wrote an article describing it here:

One Broken Pipe: Why Doctors Treat Chronic Fatigue, Diabetes, and Cancer as Separate Diseases​

 
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