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Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes, 2023 Islam et al

Discussion in 'Long Covid research' started by Sly Saint, Jan 17, 2023.

  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

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    Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes per immune dysregulation and microbial translocation in long COVID

    Abstract
    A significant number of persons with coronavirus disease 2019 (COVID-19) experience persistent, recurrent, or new symptoms several months after the acute stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

    This phenomenon, termed post-acute sequelae of SARS-CoV-2 (PASC) or long COVID, is associated with high viral titers during acute infection, a persistently hyperactivated immune system, tissue injury by NETosis-induced micro-thrombofibrosis (NETinjury), microbial translocation, complement deposition, fibrotic macrophages, the presence of autoantibodies, and lymphopenic immune environments.

    Here, we review the current literature on the immunological imbalances that occur during PASC. Specifically, we focus on data supporting common immunopathogenesis and tissue injury mechanisms shared across this highly heterogenous disorder, including NETosis, coagulopathy, and fibrosis.

    Mechanisms include changes in leukocyte subsets/functions, fibroblast activation, cytokine imbalances, lower cortisol, autoantibodies, co-pathogen reactivation, and residual immune activation driven by persistent viral antigens and/or microbial translocation. Taken together, we develop the premise that SARS-CoV-2 infection results in PASC as a consequence of acute and/or persistent single or multiple organ injury mediated by PASC determinants to include the degree of host responses (inflammation, NETinjury), residual viral antigen (persistent antigen), and exogenous factors (microbial translocation). Determinants of PASC may be amplified by comorbidities, age, and sex.

    https://academic.oup.com/jleukbio/advance-article/doi/10.1093/jleuko/qiac001/6987908?searchresult=1


     
    Peter Trewhitt, Hutan and alktipping like this.
  2. Hutan

    Hutan Moderator Staff Member

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    From the abstract, this looks like a fairly uncritical compilation of Long Covid research of varying quality.
    Most of the researchers are based in Macau (China).
     
  3. Hutan

    Hutan Moderator Staff Member

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    This is the only mention of ME/CFS, well, the name approaches ME/CFS. It's for low cortisol of course:
    But, not a whiff of psychosomaticism, so that's encouraging.
     

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