Some interesting things I didn't know before (links to S4ME threads for references): The same HLA alleles increased risk of ME/CFS and...
Preprint posted on MedRxiv, now posted with new title on SSRN, see post #4 Integrative Genome-Wide Association Studies of COVID-19...
Negative Association of Gulf War Illness Symptomatology with Predicted Binding Affinity of Anthrax Vaccine Antigen to Human Leukocyte (HLA) Class...
2016 study, but posting because there was a semi-replication of a gene from an even older GWAS [27]. Both small studies, but just some genes to...
HLA-DQB1*05:03 is associated with an increased risk of COVID-19 progression in the Bulgarian population Lukanov; Mihaylova; Al Hadra; Lesichkova;...
100% of ME/CFS and 73.3% of LC had PEM. I think the genes/pathways most likely to be important would be the ones significant in both LC and...
...2.5244207 ME12 10.640375 ME13 2.76768527 ME14 2.69310125 For HLA-DQB1 HC01 10.6659423 HC02 9.7885739 HC03 11.2015097 HC04 10.3171179 HC05...
I'm a bit confused about whether the HLA genes are differentially expressed in ME/CFS. That statement seems to say so, but Figures 2 and 3 don't...
HLA-DQA1 and HLA-DQB1 have been highlighted previously, eg — Immunometabolic changes and potential biomarkers in CFS peripheral immune cells...
See also Immune exhaustion in ME/CFS and long COVID (2024, JCI Insight)
Immune exhaustion in ME/CFS and long COVID Natalie Eaton-Fitch; Penny Rudd; Teagan Er; Livia Hool; Lara Herrero; Sonya Marshall-Gradisnik Myalgic...
• Molecular study of receptor for [AGE] gene promoter and identification of specific HLA haplotypes possibly involved in [CFS], 2009, Carlo-Stella...
...RNA sequencing (2024, Journal of Translational Medicine) — HLA-DQB1 was also highlighted in Fine mapping of the major histocompatibility...
Yes, this is likely an extremely broad self-defined LC definition. It may be worthy of note that HLA-DQA1 was once potentially implicated in CFS;...
Yujing Sun, Zhenhua Zhang, Qincheng Qiao, Ying Zou, Lina Wang, Tixiao Wang, Bo Lou, Guosheng Li, Miao Xu, Yanxiang Wang,...
@Manuel, thank you for this paper. I think it draws together many threads. I had a question about the HLA genes though. You point out that HLA...
Persistent Activation of Chronic Inflammatory Pathways in Long Covid Malika Aid; Katherine McMahan; Nicole Hachmann; Jessica Miller; Erica...
...Patients positive for HLA-DQB1*03:03 and/or HLA-C*07:04 (n = 12) had significantly higher response rate compared to patients negative for these...
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