100% of ME/CFS and 73.3% of LC had PEM. I think the genes/pathways most likely to be important would be the ones significant in both LC and...
...2.5244207 ME12 10.640375 ME13 2.76768527 ME14 2.69310125 For HLA-DQB1 HC01 10.6659423 HC02 9.7885739 HC03 11.2015097 HC04 10.3171179 HC05...
I'm a bit confused about whether the HLA genes are differentially expressed in ME/CFS. That statement seems to say so, but Figures 2 and 3 don't...
HLA-DQA1 and HLA-DQB1 have been highlighted previously, eg — Immunometabolic changes and potential biomarkers in CFS peripheral immune cells...
See also Immune exhaustion in ME/CFS and long COVID (2024, JCI Insight)
• Molecular study of receptor for [AGE] gene promoter and identification of specific HLA haplotypes possibly involved in [CFS], 2009, Carlo-Stella...
...RNA sequencing (2024, Journal of Translational Medicine) — HLA-DQB1 was also highlighted in Fine mapping of the major histocompatibility...
Yes, this is likely an extremely broad self-defined LC definition. It may be worthy of note that HLA-DQA1 was once potentially implicated in CFS;...
@Manuel, thank you for this paper. I think it draws together many threads. I had a question about the HLA genes though. You point out that HLA...
...Patients positive for HLA-DQB1*03:03 and/or HLA-C*07:04 (n = 12) had significantly higher response rate compared to patients negative for these...
...site located to LY86 and hypermethylated sites within HLA-DQB1 were found. In genome-wide studies in fibromyalgia syndrome, differential...
Jaybee, I am curious about your ME diagnosis. It seems very specific (to a non-scientist), and I'm wondering if you can explain the designation...
This thesis describes two investigations into the disease Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), specifically its genetic...
...tagged by the alleles HLA-C*07:04 (OR 2.1 [95% CI 1.4–3.1]) and HLA-DQB1*03:03 (OR 1.5 [95% CI 1.1–2.0]). These alleles were carried by 7.7%...
Yes. “Patients positive for HLA-DQB1*03:03 and/or HLA-C*07:04 (n = 12) had significantly higher response rate compared to patients negative for...
(I should have said, thanks for coming here @Manuel.) I'm not discounting the main idea, even if the proposed risk haplotypes for ME/CFS don't pan...
I had the impression that HLA alleles had been looked at in ME/CFS, and nothing had showed up with the frequency we would expect if these alleles...
...the interesting findings so far is a series of mutations in the HLA-DQB1 gene, and one in the HLA-DRB1 gene which are all associated with...
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