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I thought the discussion and conclusion were thoughtfully written, and think they are worth reading. I hope this team will be funded to do similar studies on a larger sample and that other researchers will attempt to replicate and build on the findings.

Looking carefully at cells with an electron microscope seems like a good thing to do. There were a lot of preparatory steps, and with such a small sample (2 patients, 2 controls), I think there's a real risk that an inconsistency in those steps might result in observed differences e.g. more...

B12 levels were a good thing to look at in a big fibromyalgia population, but the results aren't very impressive. The symptoms of fatigue, memory loss, brain fog, cognitive impairment numbness and neuropathy were not very well correlated with B12 levels, if at all. The 350 ng/L level was...

IACFS/ME 2022 Virtual Medical and Scientific Conference July 27 - 30, 2022 I think the conference was a useful contribution to the ME/CFS community - thanks very much to Lily Chu @hope123 and her team for what I am sure was a lot of work, and for allowing Science for ME virtual access. Click on...

I think that the data on symptoms collected on the first visit were not all that was used to diagnose someone with ME/CFS. It seems as though patients did have to be ill for more than 6 months to be diagnosed . I do wonder if the researchers knew what PEM is - it always seems to be mentioned...

@SNT Gatchaman, or anyone Associated Myalgic Encephalomyelitis Society Incorporated Is that ANZMES or another organisation??

Forty-two patients were assessed for eligibility and 32 were randomized. 3 were lost to follow-up, all in the support therapy arm, leaving 17 in the REACT treatment arm and 12 in the support therapy arm. I can't help but wonder if the cancer caused the seizures; it can happen. 2 patients in...

This quote from the first paper is interesting. My first observation is that treatment is routinely being provided to young people with PNES in the absence of evidence. This is not evidence-based medicine. The second is that the evidence for psychotherapy being useful in adult PNES patients...

Thanks to a member for access to the paper. The authors do not make clear how long the FND symptoms lasted, which surely is of substantial interest. A number of the published case studies they reference involve short-lived symptoms that occurred upon induction of anaesthesia or upon return...

Oh dear. I found this study: it used the Taiwanese health insurance research database, looking at the chances of patients developing epilepsy in the year following operations with general anaesthetic or neuraxial anaesthetic (e.g. epidural). I think it has been done well - patients were...

'Psychiatric' as in 'psychogenic' as opposed to 'affecting brain function'?

I've added tags to some of the threads relevant to Kanaan.

It could be, the abstract is unhelpfully vague. Does anyone have access to the paper?

The FND labelling is obscene. It looks as though a prior psychiatric diagnosis in a patient provides surgeons/anaesthetists with a 'get out of jail free' card when it comes to post-surgery issues. It's possible that this is actually progress - someone suggesting that some of these FND...

This figure, which is supposed to be the average of all of the data for the two groups, is a bit odd. Table 1 tells us that the heart rate for the controls during supine rest averaged 68, and the heart rate for the POTS patients averaged 71 bpm. But, look at Figure A, in the first section...

That the authors could draw their conclusion so confidently on the basis of that Figure B is amazing. That's a really substantial overlap. A control could easily have as much 'anticipatory tachycardia' as the POTS patient, although presumably the outcome on the tilt table was quite different...

Seems pretty significant in terms of recognising there is a problem. From the memorandum: It's a shame the first two symptoms of Long Covid are anxiety and depression though. And that Long Covid is seen as a 'new condition'. I guess it's good that the 'mental health crisis exacerbated by the...

I wonder if this paper aims to bolster the use of patient reported measures as primary outcomes, which would of course make trials of CBT or GET for fatigue that use e.g. the Chalder Fatigue Questionnaire ok. The context is everything, and we don't see acknowledgement of that in the abstract...

I'm skeptical about this. Cortisol changes could be a result of a change in lifestyle that happens when you are sick. The people in this sample had been sick for a while, and so there had been lots of time for lifestyles to change. If you don't have to rush to get up in the morning and deal...

Moved posts That's a brilliant presentation @SNT Gatchaman, so many quotable bits. Sadly, it still desperately needs to be heard.