Search results

Late to the party as usual. My pet peeve is the Columbia U study in 2015 that found hyperactive immune system in the first 3 years and then the depressed one after that, thus concluding that inflammation level does not predict the symptom severity. Then another paper in 2025 by the same core...

Another paper about the brain and the immune system effecting each other. In gist, ablating the neurons activated by the heat attack improved the recovery of heart muscle in mice. Might have relevance to MECFS neuroimmune hypothesis. Summary Myocardial infarction (MI) triggers adverse cardiac...

I think I got you beaten on that front. Things in my car right now: 60 qt fridge, 6" memory foam mattress, sleeping bag, skis and poles., piano kb, guitar, 2 cameras, gopro, 6 lenses, reflectix window covers, instant pot, hot plate, bags of clothes, food, electronics... Anyway, I only brought...

Well, I make no such assumption. My theory is some neurotransmitters suppress dysfunctional hypersensitivity to peripheral immune signals, but that's just my working theory. And I single out dopamine because there have been several papers that say dopamine downregulates neuroimmune systems. It's...

Yeah, I made it clear I'm my 2021 essay about the experience that it is no more than an anecdote and I don't recommend it because there is a definite risk that it can make your MECFS worse, not better. For whatever reason though, I just light up, and my mood and ability improves despite...

If u meant it doesn't work for everybody, or even most people, then I agree. Something not working for you does not mean it doesn't for everybody, no more than something that works for you does not mean it works for everybody. Don't get me wrong, I'm not proselytizing. I'm simply offering a...

It could that the covid inflammation subsides after 8-10 days. I had similar experience with my first covid while on the road in 2021. I was miserable for a week or so, and yet I was functioning fine. Then, on the second week, I felt depleted and spaced out as if my ME/CFS was coming back with...

I've been sick past a few days with what appears to be a common cold. Then I got my flu/covid vaccine yesterday, thanks to my Medicare card that finally came through. Now I'm stuck in a motel room sick, which gave me time to think about this topic of feeling better when sick. Can't say if the...

Summary Microglia are indispensable for the central nervous system (CNS) development and homeostasis, and mutations in microglia can cause microgliopathies. Correcting these mutations holds therapeutic potential, but conventional gene therapies cannot yet achieve the CNS-wide delivery required...

He discusses the paper re-analizing the GWAS study by Decode ME. To me, the paper doesn't do much more than reaffirming the genetic link of ME/CFS. He seems to go a little too far linking it to the idea of subtypes though. Perhaps he is laying foundation for his upcoming paper for...

I wasn't able to take shower for the first 3 years of my sickness. The best option was soaking in and take time to wash slowly while leaning supine in the tub. It was also therapeutic. (Drying hair was problematic though, despite short hair, because I had to raise my arms.) It was rather...

It's rather funny that they ignored the universal symptoms that define ME/CFS and then surmised from the clustering of non-core symptoms that ME/CFS is multisystemic. You'd think it would be more productive to focus on and pursue the cause of the universal ones.

We already know that symptoms tend to cluster, so I don't know what new things the paper brings. They essentially took what is known, put them in some arbitrary buckets of "functional body systems" and then concluded that these functional body systems can be the causes of those symptoms. I...

I don't know about NDRI, but I do take CNS stimulants. When I was sicker, stimulants used to bring me some comfort by partially relieving aches and lifting mood but did not improve functioning much. These days, I get huge boost when I'm under the weather: I practically become indefatigable. But...

I wonder how they know his ME/CFS drastically improved while he was critically ill. Hard to imagine him doing dishes or moving furniture while being critically ill with sepsis.

Symptom severity is the only predictions that really matters. Since there is no objective measure for it, I guess they'll have to resort to questionnaires like everybody else till someone come up with objective measures. Which brings us to my favorite topic: objective measure of exertion...

I first thought this paper was by the same NIH researcher featured in IACFS/ME conference. It is from Spain. I guess LC vesicle depletion theory is now fashionable?

At least they make testable predictions. That's more than we can say about most of the hypotheses out there. Too bad it already fails at least one prediction it makes. People have been playing HRV and the evidence seems that there is no clear correlation between HRV and symptom severity. But...

I usually explain ME/CFS as an injury caused by immune stress. He might understand that is not contagious if he also understands that an ankle sprain is not contagious. But then, someone who doesn't even bother to look up basic facts on the condition of his relation may not...

If PEM is indeed present in other conditions, I'd consider ME/CFS being a comorbidity to those conditions rather than ME/CFS not being distinct. When PEM is present in fibromyalgia, for example, they usually get ME/CFS diagnosis as a comorbidity. As for MS, I wouldn't be too surprised if there...