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Yes, this is a caveat in every fMRI study but especially so where alterations in cerebral blood flow and neurovascular coupling are suspected. I don't think this means that fMRI shouldn't be used to study ME/CFS but that the results need to be interpreted carefully, good manuscripts will include...

Ah, so I definitely was mixing up my stats principles here (it's been a long time....). I was thinking of situations in which multiple comparisons analyses are run without a significant interaction, which is the actual statistical no-no. An interaction without any main effects just indicates a...

Hey everyone, I finally gathered enough spoons to sort through some of this data myself, and it does not look good. I ran mixed effect models on the data from 4B and 4C (2way ANOVA cannot handle missing values). 4B had no main effect of block or patient group, and while there was an interaction...

It looks like it had been published on previously, although muscle physiology is way outside of my wheelhouse. This is the initial publication on the Dimitrov index: https://journals.lww.com/acsm-msse/fulltext/2006/11000/muscle_fatigue_during_dynamic_contractions.14.aspx Not sure what the...

Ah, finally some answers to the numbers problem! I mean, it's still off by several orders of magnitude, but at least it makes sense as an attempt to explain the analysis. It still strikes me as an odd choice of analysis and IMO it's misleading to not plot this with the figures to make it clear...

This is definitely what I meant but didn't explain it well, thanks for clarifying!!

Thanks all - yes I think it's a good point that they might be doing some kind of regression analysis here and then using a t-test to compare slopes. That would probably be the most straightforward answer, although again it's disappointing that we do not have any information regarding how they...

Hi everyone, I am working on my writeup of this study for my blog and I've come across what I believe might be some major issues with the statistics in this analysis, specifically in regards to the analysis of the EMG data (slope of the Dimitrov Index) and the MEP amplitude data. These are their...

Yes, neurovascular coupling is always an important caveat in BOLD fMRI studies, often an unappreciated one. There were a few labs studying this where I went to grad school. It's really difficult to measure experimentally and is basically impossible to measure accurately via fMRI alone - the lab...

Hey everyone, new to this forum but I have lots of questions with the way this study was performed/interpreted. I'm glad others have noticed the disparity between the analysis of the fMRI data versus the MEP data, specifically by not standardizing the comparisons across fatigue onset. I've been...

@SNT Gatchaman I'm about to resurrect that thread, I have questions lol. I was recently granted access to the study data too and hoping to do some re-analysis, but I'm not super familiar with this type of data analysis, so who knows how far I'll be able to get.

Ah, I've been trying to work my way through that paper as it's one of the only ones (maybe the only one?) they cite about the TPJ. It is a review paper that presents a hypothesis/framework for TPJ function. This is somewhat outside my area of expertise, but they detail at least half a dozen...

Just wanted to chime in and say thanks for this extensive investigative work @Arvo, I'm going to cover some of this in my blog, maybe even write a separate post about it.

This is a very uninformed answer. He appears to be conflating the concept of reward-prediction error in dopamine processing and the initiation of motor actions. The fMRI results did not show any changes in blood flow to areas of the brain associated with reward calculation - ventral tegmental...

I am actually working on a blog post for this purpose, but it's taking quite some time. I'm glad to have found this forum as the folks here are discussing the same issues I noted during my detailed read-through. I am also going through most of their citations to determine whether the information...