I don't know if this thread is the right place or not but @paulendat mentioned that ACOD1/IRG1/Itaconate is highly expressed in microglial cells....
Did you watch the 2023 video from the NIH webcast (post about it)? Testing results showed no difference in Interferon-alpha (at 1 hr 10 mins) but...
For those that have data a person with ME/CFS has provided a genetic panel screening tool called GenVue which has been around since 2012 (old name...
For doctors there is a screening panel they can order. You need the specialist to choose the right selection of panels in case it is not the...
I guess one question I have from having looked at public cell expression databases, IRG1/ACOD1 is also highly expressed in Monocyctes. We know...
I enjoiyed the talk, however most of the talk was above my understanding. The key part for us thinking about PEM seems to be that Itaconate has a...
To clarify this for those that are not aware, from what I remember from having watched the videos a year or two ago, the itaconate shunt...
One thing I was surprised NOT to read about. Having ME/CFS clinics tied to research. If my reading of @Jonathan Edwards posts about his ground...
In Robert Phair's Itaconate shunt webinar he stated that IFN-alpha measurements are often several orders of magnitude off. This paper has...
I understand that there can be doubt when a skin biopsy shows you are in the 4th percentile of the population. There must be variation sample to...
I'm interested in a Janet and John story about p-values and what they really mean. Is 0.05 completely arbitrary? Where did the 0.05 come from....
From my understanding of Robert Phairs technical description the innate immune system can affect CAD via interferon-alpha/JAK pathway and that...
Talk by Mark Davis on the rare CD4 T cell type is here starting at 4hrs 48mins https://videocast.nih.gov/watch=42563 He talks about classical...
Regarding CD4 cells Mark Davis gave a talk at the NIH Fatigue Conference/Webinar Sep 2021 that Jamie Seltzer transcribed on Twitter. He presented...
That's interesting that Lansoprazole and ranitidine are both shown - both used to reduce stomach acid. Makes me think of Dr Chia and his link of...
I took two separate treatment courses of Acupuncture by certified practitioners a little before becoming severe. One had trained in China and been...
FYI - Stanford has a Biolog Omnilog instrument that measures mitochondrial function and in my limited understanding you can try various compounds...
Cornell got $1000MM pulled, NorthWestern $800MM and now Harvard, all on top of Columbia. CDMRP PRMRP totally gone which was funding Stanford,...
I suspect the earlier studies did not control food intake or have rapid sample stabilization and processing after collection. Many metabolites...
Have you thought of contacting Robert Phair - he has built a very detailed model of the TCA cycle over many years specifically to test hypothesis...
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