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  1. John Mac

    Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion in Long COVID with ME/CFS, 2026, Elahi et al

    Full title: Single-cell analysis reveals immune remodeling of monocytes, NK cells, T cell exhaustion, and Galectin-9–associated depletion of gamma delta and mucosal-associated invariant T cells in Long COVID with ME/CFS The cellular mechanisms underlying Long COVID (LC) associated with myalgic...
  2. John Mac

    Trial Report Vitamin D in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after COVID-19 or Vaccination: A Randomized Controlled Trial, 2026, Kodama et al

    Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can develop as post-vaccination syndrome (PVS) or Post-Acute Sequelae of SARS-CoV-2 infection (PASC). In our prior retrospective study, most patients with PVS who developed ME/CFS had vitamin D insufficiency or...
  3. John Mac

    The landscape of hereditary haemochromatosis risk and diagnosis across the British Isles and Ireland 2026 Wilson et al

    I was tested twice for haemochromatosis, once by the NHS and once privately at a Spire hospital but both tested negative for the gene variant. I was feeling unwell and when I had my blood tests done by my GP my iron levels were reading 760 where the upper limit was 300 ( sorry can't remember the...
  4. John Mac

    News from Germany

    https://www.ndr.de/ndr2/epg/NDR-2-Spezial,sendung-48920.html NDR 2 Spezial: ME/CFS - die unerforschte Krankheit Donnerstag, 05. Februar 2026, 18:00 bis 19:00 Uhr ME/CFS – Nur fünf Buchstaben. Aber für hunderttausende, alleine in Deutschland, eine Diagnose, die das ganze Leben verändert. Die...
  5. John Mac

    The Potential Causes Of Myasthenia And Fasciculations In The Severely Ill Me/Cfs-Patient: Role Of Disturbed Electrophysiology, 2025, Wirth et al.

    Now published https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2025.1693589/full
  6. John Mac

    Review POTS, ME/CFS and Long COVID as Neuroimmune Disorders, 2026, Blitshteyn et al

    Full title: Postural Orthostatic Tachycardia Syndrome, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID as Neuroimmune Disorders Abstract: Postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and Long COVID are...
  7. John Mac

    NHS Sussex Community NHS Foundation trust: Myalgic Encephalomyelitis (ME) and Chronic Fatigue Service (CFS)

    Merged thread. Sussex Community NHS Foundation Trust No mention of PEM?
  8. John Mac

    Review Imbalance of Excitatory and Inhibitory Neurotransmitter Systems in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2026, Wirth & Scheibenbogen

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and post-COVID-19 syndrome share a symptom profile, including severe fatigue, cognitive dysfunction, exertional intolerance, sleep disturbances, hypervigilance, and the paradoxical state of being “wired but tired.” A...
  9. John Mac

    BBC: Changes to flagship disability scheme don't go far enough, campaigners say

    Changes to a flagship scheme that encourages firms to employ more disabled people don't go far enough, campaigners say. Disability Confident, a voluntary employer scheme, was launched in 2016 to get more businesses to recruit and retain disabled people. It had faced criticism, including from...
  10. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2026

    Benefits & Work Newsletter FEWER PIP REVIEWS, MORE WCA REASSESSMENTS, MORE FACE-TO-FACE From April 2026, the time between PIP reviews is to be extended for the majority of claimants aged 25 and over, to a minimum of three years for a new claim, rising to 5 years at their next review. The...
  11. John Mac

    Large-scale investigation confirms TRPM3 ion channel dysfunction in ME/CFS, 2025, Marshall-Gradisnik et al

    https://news.griffith.edu.au/2026/01/13/new-research-confirms-people-with-me-cfs-have-a-consistent-faulty-cellular-structure/
  12. John Mac

    MDPI: POTS, ME/CFS and Long COVID: Recent Advances and Future Direction

    Journal of Clinical Medicine: Special Issue Deadline for manuscript submissions: 20 January 2026 Special Issue Information Dear Colleagues, Postural orthostatic tachycardia syndrome (POTS), myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and long COVID are complex syndromes caused...
  13. John Mac

    Development and validation of blood-based diagnostic biomarkers for [ME/CFS] using EpiSwitch®… 2025, Hunter et al. (Oxford Biodynamics)

    Response to the study Wheat and chaff in Myalgic Encephalomyelitis/Chronic fatigue syndrome (ME/CFS) in clinics and laboratory First, the article repeatedly asserts that “immune dysregulation” is a hallmark of ME/CFS, citing elevated pro-inflammatory cytokines and natural killer (NK) cell...
  14. John Mac

    Article: Could this palm scan read your body better than a blood test?

    "So when I first heard about OligoScan, the non-invasive palm scan that measures levels of essential minerals, trace elements, and toxic heavy metals stored intracellularly within the body’s tissues, I wanted to find out more". Reads like an advert.
  15. John Mac

    Enduring symptoms: A call to immediate action, 2025, Barnes

    By David Tuller, DrPH As part of its December issue, Future Healthcare Journal, sponsored by the UK’s Royal College of Physicians, has published a special section called “Challenging Myths: Debunking Functional Disorders.” The special section title itself creates confusion. In what way are...
  16. John Mac

    Age-specific alterations of the gut mycobiome in patients with ME/CFS and identification of potential diagnostic biomarkers, 2025, Wei Guo et al

    Abstract Background While bacterial dysbiosis and metabolic disruptions have been widely implicated in the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), the contribution of the gut mycobiome remains largely unresolved, particularly in the context of host age...
  17. John Mac

    Treatment for ME has turned a corner - the UK must not leave patients waiting, 2025, Chowdhury

    Let’s make this the decade we finally develop treatments for this condition, writes Sonya Chowdhury 2025: A breakthrough year for ME, but we must go further Too many people – including, devastatingly, many medical professionals - have dismissed it as ‘all in the mind’. This characterisation...
  18. John Mac

    Review Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Insights into Disease Mechanisms, 2025, Nikolova et al

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a disabling clinical condition, whose hallmark characteristic is post-exertional malaise (PEM). It can affect many organs and systems, leading to severe impairment of patients’ quality of life. Although numerous...
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