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I don't have the energy for more, sorry @Utsikt!

I think it's reasonable to check whether muscle strength training improves functional capacity in any well-defined disease, the problem here being the mish-mash of patients who would be scooped into this study. From its description, I don't see a reason why the Shuttle Walk Test would be less...

I don't know for sure, @Trish, but I would guess that they wouldn't assign you to the ambulatory group. My guess is that they would start you in bed-bound. The manual says: That depended on how hard people found each exercise. If I'm understanding correctly, for the first 2 weeks, the...

It would be interesting to know what the percentages were at baseline.

I'm not clear on which part of their rationale you don't agree with, because you don't need lack of X to be the cause of Y in order for X to improve Y - think of rehabilitation in an area like stroke where there's good evidence of benefit. Which bit of their rationale do you object to:

Yeah, the usual argument put forward is that by doing exercise you would be able to do more of those things that have a practical purpose or social benefit, but that doesn't seem to pan out for us, does it? I remember well what it was like when exercise had that effect - it was great, like a...

If I've understood correctly, they found that the resistance exercise intervention did not help chest pain, breathlessness or fatigue more than standard care (which included access to rehabilitation). So if you had been in the intervention arm of the study, you would probably have withdrawn...

A study author sent me a draft manual for the exercise intervention in this study. It’s by Gray, Boiskin & Berry and is dated February 2021. I don’t have permission to share it, but I do have permission to summarise it and quote from it. I’ll summarise it in terms of what’s similar and...

Ambulatory Upper body exercises Press-ups Standing arm raises Seated rows Chest stretches (no video) Lower body exercises Lunges Calf raises Shared with permission from Prof Stuart Gray, who was in charge of the exercise intervention.

Able to sit up Upper body exercises Seated chest-press Seated row (no video) Seated arm raises Chest stretches (no video) Lower body exercises Seated leg extensions Seated toe pointing Squats (no video) Shared with permission from Prof Stuart Gray, who was in charge of the...

Confined to bed Upper body exercises Lying chest-press Lying row Lower body exercises Lying toe points Lying leg press Bridging Shared with permission from Prof Stuart Gray, who was in charge of the exercise intervention.

In the next few posts, I am sharing youtube links for the exercises participants did in this study, with permission from Prof Stuart Gray, who was in charge of the exercise intervention. In each case, participants did the upper body exercises from the start, and added in lower body exercises...

Agree. Back in 2016 when the plan for the NIH study was presented in a webinar, my father (a medical researcher) wrote to Nath to urge them to study patients with severe ME/CFS for exactly this reason. His work was in neural tube defects, and if I remember correctly, his group was not getting...

I haven't looked at reaction times - I have a feeling someone ruled out an issue there early on, but I could be wrong. However, I have looked at button press rates, and I think there's something there. They were beyond the scope of our piece, but it is something that @andrewkq and the rest of...

There was a bit of conversation above about an email Prof Treadway sent to a forum user in March 2024. In September 2024, John Bolecek wrote here:

Yeah, you're right. I'm going to be obnoxious and quote myself Kirke 2018!

Indeed. Yes, we submitted our manuscript to Nature Comms as a Matters Arising. When you’re submitting a Matters Arising, you’re “strongly encouraged” to first send it to the authors, and we did this in July 2024. We had an extensive email exchange with the NIH team in July and August 2024...

Actually, a really nice part of this project was getting to read plenty of fascinating psychology articles that I had not come across before (e.g. the ones we cited on motor speed and processing speed), and discovering how effort-based decision-making has been studied in other conditions like...

Thanks everyone. We worked really hard on this for a long time. So we are delighted that it has now been published. This was a really fun collaboration, which was just as well, as we ended up having to do so much work together. I would work with @andrewkq, @OscarJunge, @Jonathan Edwards and...

I'm thinking about how your model explains the effect of exertion in ME/CFS @Jonathan Edwards : I'm interested to know whether White et al.'s 2011 study findings are consistent with your proposed mechanism? They compared controls, people with multiple sclerosis and people with CFS after a...