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Perhaps of interest: Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial cell activation Maybe the elevated VWF seen in the LC patients is non-specific and just reflecting some sort of inflammation or maybe it is...

Does anyone know which parameters they were looking at in blood (@chillier)? Given the results in Increased von Willebrand and Factor VIII plasma levels in gynecologic patients with Post-Acute-COVID-Sequela (PASC)/Long COVID and other research by Pretorius and others, I hope it includes von...

Pretorius & Kell did report elevated VWF in Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19, though definitely not as dramatic as the results here. I hope that the Dalton / Sheffield microclots study (also in women only) is looking at VWF, d-dimer, etc.

Significant differences: And maintained over a couple years: But a very small cohort and even fewer controls, 60% with cancer, older and all female. Only 2/5 controls reported covid infection. Not clear how they define LC. Overall though, this seems to be in line with what we've seen from...

Stefania Bellone, Eric R. Siegel, David E. Scheim, Alessandro D. Santin Highlights Growing evidence suggests that persistent microvascular inflammation, clumping/clotting of blood cells and thrombotic complications may be key causes of Long COVID. Plasma levels of von Willebrand factor and...

Discussing this on Twitter so I made a plot showing the individual changes (I've removed one LC patient who didn't have both baseline and PEM data). Two figures here, same data as figure 4B for both, one separating controls and LC and one combining them. This looks less meaningful to me than...

This paper seems like it might be relevant to the amyloid in muscle question: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle Abstract: A dominant histopathological feature in neuromuscular diseases, including amyotrophic lateral sclerosis and inclusion body myopathy, is...

They did see the amyloid deposits (or whatever they might be staining with Thioflavin T) in LC before exercise. Not really a huge change after either (excepting those three outliers with very high densities). I suppose the baseline high amyloid deposits density in LC would be pretty easy to...

One of fatigue, shortness of breath, confusion, headache, altered taste and smell, joint pain, muscle aches, cough, chest pain, scratchy throat, nausea, vomiting, diarrhea, fever, chills, red or painful eyes, sore throat, and other at 5.4 months after infection is probably not a very helpful...

Apparently, these are two different groups, based on some kind of EEG data from a sound repeated 100ms later. Supposedly, these two figures are showing the same data, but they clearly are not, so I'm not really sure what's going on here and don't have much faith in this study. I'd also...

This looks like they went on a fishing expedition by comparing all kinds of things and found one variable that was different. Yes, it looks like only one of their ICU patients didn't get LC. So even if they did find something real, it looks more like a result of being the ICU than anything else.

The absolute increase in amyloid-containing deposits after exercise testing was similar between controls and patients, which suggests maybe there could be a problem clearing them or whatever happens normally, rather than a problem of too much being deposited (unless the amyloid-containing...

Of the 14 genes identified in Precision Life's ME/CFS paper, only PHACTR2 meets the threshold in this paper (associated with 5 circulating miRNAs). But I don't think we would expect overlap between these lists of genes, as the causality is running the opposite way (in Precision Life's analysis...

The author has updated his cost estimate in this PDF, mostly based on ME/CFS. He assumes people with 3+ LC symptoms are at 0.71 QALY for five years and 70% of them are out of work. That seems a little high to me for the number of people out of work, but probably in the ballpark. The five years...

I'm not sure I'm understanding this correctly, but I think the hypothesis here is: A variety of circulating miRNAs are elevated in ME patients' blood, but overall these miRNAs inhibit a comparatively smaller set of genes, many of which are functionally related and could plausibly be connected to...

Looks like they only found high lactate in roughly half of the patients: Maybe this would be one to test in a PEM state (ideally PEM due to cognitive exertion).

NICE says an intervention should be below £20,000 - £30,000 per QALY gained to be cost effective. So their approach is very much aimed at getting NICE to accept FITNET, which of course they missed by a mile here. Edit: Here's a link about evaluating digital health products, which seems quite...

You might be right. They say they adjusted for "baseline utility for QALYs", but that could also mean they adjusted between the groups to balance them. I'd be surprised if they even enrolled patients with that low of a quality of life on average though, let alone after the inevitable regression...

Hard to know exactly what they are claiming from the poster, but it looks like they are just looking at one year, in which case a 0.53 QALY gain is huge. That's essentially going from quite sick (somewhere around 0.4-0.5) to perfectly fine. But I think the scale they are using here actually...

I think blinding would be a significant issue with the IR LEDs too. Looking up the specs for the LEDs they used, each one is 0.135W x 300 LEDs = 40W of heating. That's more power per unit area than an electric blanket, so you'd definitely feel the warmth. But overall this seems almost too good...