Perhaps of interest: Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID-19): evidence of acute and sustained endothelial...
Does anyone know which parameters they were looking at in blood (@chillier)? Given the results in Increased von Willebrand and Factor VIII plasma...
Pretorius & Kell did report elevated VWF in Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19, though...
Significant differences: [ATTACH] And maintained over a couple years: [ATTACH] But a very small cohort and even fewer controls, 60% with...
Stefania Bellone, Eric R. Siegel, David E. Scheim, Alessandro D. Santin Highlights Growing evidence suggests that persistent microvascular...
Discussing this on Twitter so I made a plot showing the individual changes (I've removed one LC patient who didn't have both baseline and PEM...
This paper seems like it might be relevant to the amyloid in muscle question: TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle...
They did see the amyloid deposits (or whatever they might be staining with Thioflavin T) in LC before exercise. Not really a huge change after...
One of fatigue, shortness of breath, confusion, headache, altered taste and smell, joint pain, muscle aches, cough, chest pain, scratchy throat,...
Apparently, these are two different groups, based on some kind of EEG data from a sound repeated 100ms later. Supposedly, these two figures are...
This looks like they went on a fishing expedition by comparing all kinds of things and found one variable that was different. Yes, it looks like...
The absolute increase in amyloid-containing deposits after exercise testing was similar between controls and patients, which suggests maybe there...
Of the 14 genes identified in Precision Life's ME/CFS paper, only PHACTR2 meets the threshold in this paper (associated with 5 circulating...
The author has updated his cost estimate in this PDF, mostly based on ME/CFS. [ATTACH] He assumes people with 3+ LC symptoms are at 0.71 QALY for...
I'm not sure I'm understanding this correctly, but I think the hypothesis here is: A variety of circulating miRNAs are elevated in ME patients'...
Looks like they only found high lactate in roughly half of the patients: [ATTACH] Maybe this would be one to test in a PEM state (ideally PEM...
NICE says an intervention should be below £20,000 - £30,000 per QALY gained to be cost effective. So their approach is very much aimed at getting...
You might be right. They say they adjusted for "baseline utility for QALYs", but that could also mean they adjusted between the groups to balance...
Hard to know exactly what they are claiming from the poster, but it looks like they are just looking at one year, in which case a 0.53 QALY gain...
I think blinding would be a significant issue with the IR LEDs too. Looking up the specs for the LEDs they used, each one is 0.135W x 300 LEDs =...
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