Preprint Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination, 2024, Aamodt et al.

Discussion in 'Long Covid research' started by SNT Gatchaman, Oct 23, 2024.

  1. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    Altered amyloid plasma profile in patients with disabling headaches after SARS-CoV-2 infection and vaccination
    Anne Hege Aamodt; Thor Ueland; Marion Boldingh; Burcu Ella Bezgal; Mari Argren; Cecilia Adele Dunne; Kari Otterdal; Ida Gregersen; Vigdis Bjerkeli; Annika Elisabet Michelsen; Andreas Husoey; Aase Hagen Morsund; Kristina Devik; Anne Christine Poole; Kristine Bodding Gjendemsjoe; Katrin Schluter; Sara Maria Mathisen; Mari Aalstad-Johansen; Thor Haakon Skattoer; Julie Soennervik; Turid Birgitte Boye; Trine Haug Popperud; Einar August Hoegestoel; Fridtjof Lund-Johansen; Paal Aukrust; Erling Tronvik; Tuva Boerresdatter Dahl; Bente Halvorsen

    BACKGROUND AND OBJECTIVES
    New onset persistent headache has been reported following acute COVID-19 disease and to some degree also after SARS-CoV-2 vaccination. Still, the mechanisms for these headache types are unclear. The purpose of this study was to assess levels of amyloid related biomarkers in patients with persistent headache after COVID-19 and SARS-CoV-2 vaccine.

    METHODS
    In this prospective observational cohort, patients with severe headache as the dominating symptom after COVID-19 disease (n=29) and SARS-CoV-2 vaccination (n=31), had neurological assessments with reassessments after 6 months. Plasma levels of amyloid precursor protein (APP), pregnancy zone protein (PZP), cathepsin L1 (CTSL) and serum Amyloid A (SAA1) were measured by ELISA in relation to levels in healthy controls (n=16).

    RESULTS
    We found a strong and persistent upregulation of APP in patients with headache after COVID-19 as compared to the two other groups. At both inclusion and after 6 months APP levels were also increased in those with accompanying cognitive symptoms. In contrast, plasma levels of PZP were elevated in both headache groups as compared to healthy controls at inclusion and after 6 months follow-up, but with no relation to cognitive symptoms. CTSL was only elevated in those with COVID-19 associated headache at baseline, whereas SAA1 showed levels comparable in all groups.

    CONCLUSIONS
    Altered plasma levels of soluble markers potentially reflecting changes in amyloid processing was found in patients with persistent headache after SARS-CoV-2 vaccine and particular in those with persistent headache after COVID-19 disease where we also found some association with cognitive symptoms.


    Link | PDF (Preprint: MedRxiv) [Open Access]
     
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  2. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    What is already known on this topic
    New onset persistent headache occurs in a subset of individuals after COVID-19 and to some extent after SARS-CoV-2 vaccine. However, the pathophysiological mechanisms are unknown.

    What this study adds
    There was high disability with only modest improvement after 6-month follow-up.

    Altered plasma levels of soluble markers that potentially could reflect changes in amyloid processing was found in patients with persistent headache after SARS-CoV-2 vaccine and particular in those with persistent headache after COVID-19 disease with association to cognitive symptoms.

    How this study might affect research, practice or policy
    Our data point to plausible mechanism of amyloid processing and neuroinflammation in relation to COVID-19 and SARS-CoV-2 vaccine.
     
    Sean likes this.
  3. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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    !!

    (Remember kids, the first rule of somatoform disorders is never biologically investigate.)
     
  4. SNT Gatchaman

    SNT Gatchaman Senior Member (Voting Rights)

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  5. Sean

    Sean Moderator Staff Member

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    Second Rule: If an association with a biological variable becomes undeniable, then make sure the direction of causation is always assumed to be psyche–>soma.
     
    Last edited: Oct 24, 2024

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