Fluoxetine promotes IL-10–dependent metabolic defenses to protect from sepsis-induced lethality, 2025, Robert M. Gallant et al

Abstract
Selective serotonin reuptake inhibitors (SSRIs) are some of the most prescribed drugs in the world. While they are used for their ability to increase serotonergic signaling in the brain, SSRIs are also known to have a broad range of effects beyond the brain, including immune and metabolic effects.

Recent studies have demonstrated that SSRIs are protective in animal models and humans against several infections, including sepsis and COVID-19; however, the mechanisms underlying this protection are largely unknown.

Here, we mechanistically link two previously described effects of the SSRI fluoxetine in mediating protection against sepsis. We show that fluoxetine-mediated protection is independent of peripheral serotonin and instead increases levels of circulating interleukin-10 (IL-10). IL-10 is necessary for protection from sepsis-induced hypertriglyceridemia, preventing cardiac effects including impairment of glucose oxidation, ectopic lipid accumulation, ventricular stretch and possibly cardiac failure.

Our work reveals a beneficial “off-target” effect of fluoxetine, and reveals a protective immunometabolic defense mechanism with therapeutic potential.
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New Study explains how antidepressants can protect against infections and sepsis

Salk scientists discover SSRI Prozac regulates immune response and prevents sepsis in mice, demonstrating potential new use for the popular drug.
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Who is the intended target of this research? Sepsis and infections are, as far as I'm aware, not exactly predictable in most ordinary people. So are people supposed to take Prozac (aka fluoxetine) every day "just in case"?