Modulation of Energy Expenditure by Estrogens and Exercise in Women, 2018, Gavin, Kathleen M et al

Abstract
Reducing estrogen in women results in decreases in energy expenditure, but the mechanism(s) remain largely unknown. We postulate that the loss of estrogens in women is associated with increased accumulation of bone marrow–derived adipocytes in white adipose tissue, decreased activity of brown adipose tissue, and reduced levels of physical activity. Regular exercise may counteract the effects of estrogen deficiency.

Key Points

• Women transitioning through the menopause experience a decrease in fat-free mass, including bone and skeletal muscle, and an increase in fat mass, which is predominantly in the abdominal region. Studies in animals suggest that this is related to the loss of estrogens.
• In humans, we have shown that reducing endogenous estradiol results in decreases in energy expenditure and increases in visceral adiposity. Our research is focused on understanding the mechanisms by which this occurs.
• We have found that estrogen deficiency increases the accumulation of bone marrow–derived adipocytes in white adipose tissue of mice and decreases physical activity in women. Our preliminary data also suggest that estrogen may regulate brown fat activity. We postulate that collectively, these changes contribute to the observed decreased energy expenditure and increased central adiposity.
• We hypothesize that regular exercise may help to counteract the effects of estrogen deficiency by attenuating the observed detrimental metabolic alterations.

https://journals.lww.com/acsm-essr/...of_Energy_Expenditure_by_Estrogens_and.6.aspx

 

Very tricky slope with M.E. I can barely climb stairs since menopause.