Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction, 2022, Anna S. Monzel et al

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ are misleading misnomers that fail to capture the complexity of mitochondrial biology.

To increase the conceptual and experimental specificity in mitochondrial science, we propose a terminology system that distinguishes between (1) cell-dependent properties, (2) molecular features, (3) activities, (4) functions and (5) behaviors. A hierarchical terminology system that accurately captures the multifaceted nature of mitochondria will achieve three important outcomes.

It will convey a more holistic picture of mitochondria as we teach the next generations of mitochondrial biologists, maximize progress in the rapidly expanding field of mitochondrial science, and also facilitate synergy with other disciplines. Improving specificity in the language around mitochondrial science is a step towards refining our understanding of the mechanisms by which this unique family of organelles contributes to cellular and organismal health.
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I'm not generally excited about terminology advances, but I think this one might actually be useful. Imagine trying to diagnose car problems if your only terms were "vrooming" and "not vrooming".

 

Yes but does it help to divide vrooming into active vrooming, functioning vrooming and vrooming behaviour?

 

Psychologists forced to do mechanical maintenance would be amusing. "The problem is that your car just isn't trying hard enough."