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Prolonged impacts of COVID-19-associated cystitis: A study on long-term consequences 2023 Wittenberg et al

Discussion in 'Long Covid research' started by Andy, Dec 12, 2023.

  1. Andy

    Andy Committee Member

    Messages:
    22,399
    Location:
    Hampshire, UK
    BACKGROUND The Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 virus is an international health concern with substantial morbidity and mortality. COVID-associated cystitis (CAC), presents as new onset or exacerbated urinary symptoms, resembling overactive bladder (OAB) symptoms. AIM To examines the long-term outcomes of patients with CAC in the context of Long COVID.

    METHODS A cohort of 350 patients admitted to Detroit Hospitals with COVID-19 between May and December 2020, displaying CAC symptoms following discharge, was prospectively followed. Initial urologic evaluations occurred at 10-14 wk and were repeated at 21-28 mo post-discharge. Symptoms were managed conservatively, employing behavioral modifications and standard OAB medications. Participants completed surveys assessing urinary symptoms and quality of life (QoL) at both time points. The primary outcome was the Urology Care Foundation Overactive Bladder Assessment Tool.

    RESULTS 87% of the final cohort (n = 310) reported symptom improvement at 21-28 mo post-discharge. Patients with new onset CAC symptoms showed a median decrease of 9-10 points in OAB and QoL scores, while those with existing symptoms experienced a decrease of 6 points. Overall, 95.4% of patients with new onset symptoms reported symptom improvement at follow-up, contrasting with 60.7% among those with existing symptoms.

    CONCLUSION This study presents the first long-term follow-up of adult patients with CAC, revealing a promising prognosis with conservative management measures in the context of Long COVID. These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health. Key Words: COVID associated cystitis, COVID-19, Long COVID, Overactive bladder

    Core Tip: Coronavirus disease (COVID)-associated cystitis (CAC), presents as new onset or exacerbated urinary symptoms that may resemble overactive bladder symptoms. To our knowledge, this study is the first long-term follow-up of adult patients with CAC. Our data reveals a promising prognosis with conservative management measures in the context of Long COVID. These findings provide reassurance to patients regarding symptom resolution and underscore the need for further research into this evolving aspect of COVID-19's impact on urological health.

    Open access, https://www.wjgnet.com/2307-8960/full/v11/i33/7987.htm
     
    Andy, Dec 12, 2023
    #1
    Hutan, DokaGirl and Sean like this.
  2. Hutan

    Hutan Moderator Staff Member

    Messages:
    27,992
    Location:
    Aotearoa New Zealand
    An alternative possibility to 'overactive bladder' which, from the abstract the authors don't consider, is that people with post-Covid ME/CFS may find that they are more prone to infections. I think a number of us with ME/CFS do find that we get flares of cold sores, or infections of various sorts when we do too much.

    So, rather than an overactive bladder, it may be that the control of a chronic bladder infection is lost during periods of PEM. Over time, as people adjust their lifestyle to reduce activity and/or recover to some extent from ME/CFS over that initial two years when improvement is most likely, they may find that infection control improves.

    There is increasing awareness that many people do get chronic bladder infections and that the standard tests very frequently aren't good at identifying them.
     
    Hutan, Dec 12, 2023
    #2
    Sean, alktipping, Trish and 1 other person like this.

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