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Answer #2 in how to market results from a blinded placebo controlled trial: focus on something entirely different from the planned outcomes. Here are the main results, comparing improvements in cohorts with the treatment and a placebo: So, it looks as though more patients treated with...

Sorry for my skepticism, but this looks like a lesson in 'how to get around the problems created by a blinded placebo controlled trial'. Answer 1: 'very detailed post hoc stratification' The measure, exercise treadmill tolerance, as measured once at baseline and once at trial end seems less...

The long obfuscatory march through the alphabet of acronyms continues.

A number of posts about Björn Bragée's appearance on tv, talking about his research on ME/CFS and hypermobility have been moved to this thread: Signs of Intracranial Hypertension, Hypermobility and Craniocervical Obstructions in patients with ME/CFS (Pre-print 2019/published 2020) Bragée et al

Thanks @DMissa, that does help a lot. So, Complex V is making ATP and using oxygen to do it. When you stop Complex V from making ATP with the inhibitor, the use of oxygen should drop. How much it drops is an indication of how much ATP the Complex V was making before you inhibited it. Like...

CFS sample: 8 females, 1 male control sample: 9 females, 2 males I wondered about this, but the y axis labels (OCR pmol/min/ug protein) are exactly the same for the charts that are supposed to show basal respiration e.g 2a as the ones supposed to show ATP production e.g. 2c.

I think the figure references might be wrong here? Should it be "2A, E" as per the charts in my post above? Chart 2C is actually of ATP production. Using glucose as a substrate: Figure 2c is supposed to to be of ATP production. I don't understand the y-axis unit. Is that an error? How is...

The paper is open access. 9 CFS patients, 10 controls Glucose as a substrate for skeletal muscle cells A. Basal respiration - note significance between healthy controls and CFS - **. Pretty good. OCR is oxygen consumption rate. E. Maximal respiration - The cells were stressed somehow and...

Yes, I guess the oddness I mentioned was that Maureen had tried really hard to get across the idea of PEM to any clinicians listening. And Ian Lipkin didn't put his experience into context with that, at least I don't think he did. It would have been good if he had said, not all post-covid...