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Looks interesting. A previous preprint on LC also pointed to problems with the complement system: https://www.medrxiv.org/content/10.1101/2023.10.26.23297597v1 And it was also highlighted in some ME/CFS studies for example here: https://www.mdpi.com/2077-0383/10/18/4171

Useful to be able to test the questionnaire like this. Thanks to raffbenato for coding this.

They argue that CBT increased the connectivity between the sensorimotor network (SMN) and posterior default mode network (DMN) compared to the waiting list. It seems that it was mostly the connectivity that decreased in the waiting list condition, rather than improvements in the CBT group...

I suspect that ME/CFS is more prevalent in similar population groups (although we can't really know for sure at this point).

I suspect this is the actual research article presenting the data, but I'm not sure because it is behind a paywall. NEWS AND VIEWS 10 January 2024 Prehistoric events might explain European multiple sclerosis risk An exploration of more than 1,600 ancient Eurasian genomes suggests that...

Merged thread NEWS 10 January 2024 Ancient DNA reveals origins of multiple sclerosis in Europe A huge cache of ancient genomes spanning tens of thousands of years reveals the roots of traits in modern Europeans. [...] Europe was settled by anatomically modern humans in three main waves...

Had a quick look at the R file they used for the statistical analysis and I think that the errorbars in figure D and E are just a standard deviation from the mean. For the healthy group they show it going upward, and for the Long Covid group going downward. The statement 'the whiskers show the...

Lots of results in this paper. They annotated 116 metabolites in skeletal muscle and 83 metabolites in venous blood. Many amino acids were not different between groups at rest, but tended to be lower in patients upon the induction of post-exertional malaise. TCA cycle metabolites were lower in...

The exercise results for 25 Long Covid patients showed poorer ventilation function, which some similarities to what Cook et al. found in 99 ME/CFS patients compared to fitness-matched controls. Cook for example also found higher VE/VCO2. (This is from figure 3 in the supplementary material).

The patients in the study reported improvement, but on average, not the spectacular remission/recovery that has been reported in the ME/CFS community. Karnofsky scores changed from 50 to 60 and here are for example the changes in orthostatic intolerance: Because there was no control group we...

Quote from the paper: "A sizable amount of the main findings from this analysis are consistent with experimental data in ME/CFS. Firstly, the most inhibited gene by far is VEGFA, coding for the Vascular Endothelial Growth Factor, a major secreted mediator of angiogenesis. Indeed VEGF-A levels...

The main reason is that it was a feasibility study with only 17 patients and no controls so I do not have high confidence in the results yet. The methods used however look like an important step in the right direction.

Thanks!

We've written a review of the most interesting ME/CFS studies of 2023. Would be interesting to hear if we missed any important studies that should have been included. https://mecfsskeptic.com/2023-looking-back-on-a-year-of-me-cfs-research/ This was quite a lot of material to process so there...

Background article here: Google DeepMind used a large language model to discover new math | MIT Technology Review

Noticed this recent Nature article where a large language model was able to help with solve or optimize the solutions of Math problems. Mathematical discoveries from program search with large language models Bernardino Romera-Paredes, Mohammadamin Barekatain, Alexander Novikov, Matej Balog...

I thought it might be useful to create a thread to organize news on what Artificial Intelligence is able to achieve. Its applications might be useful for ME/CFS advocacy and research.

Some quotes from patients being interviewed: "I can’t really deal with that…one by one friends disappeared I’ve also become a bit of a recluse because I find socialising very exhausting and it’s cut me off a lot from friends and family…I couldn’t be any more different to the person I was...

Looks like a useful paper. I think loneliness is an often overlooked but severe consequence of having ME. The authors proposes two novel conceptual contributions to the study of loneliness: necessitated social isolation (due to symptoms of ME) and compelled loneliness (due to stigma of ME). She...

So this paper simply mentions that one of the 3 patients they described in an earlier paper, had relapsed, then got another surgery and improved again.