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Very good points! Thank u, will include :thumbup:

I did an interview today with Dagbladet (Norwegian Newspaper), which will be doing a bit on the petition I did for wanted methodological changes to the LP-study. I am mainly focusing on the fact that subjective outcomes is worthless alone here due to the nature of the intervention (ignoring...

My life is complete I have finally seen Jonathan go absolutely livid in full CAPS LOCK :woot:

@MSEsperanza Yes ur right in the publication its strongly suggested he means music has an effect on ME in the conclusion: "the increased recovery rate after 15 months in the intervention group might indicate that mental training for postinfectious CF is clinically useful.". If i remember...

"Smearing campaigns doesn't strengthen the patients' interest" It certainly does :laugh: The participants had lower reported activity at study end, and even so this charlatan states publicly that music is an effective treatment for ME. For ME! Its ridiculous, and almost nobody else than the...

"The "specific antibodies" we know of in Cfs, and you can ask Prof. Edwards he will agree with me, are found in many other diseases as side effects." That was not my point, i meant that even if we have tested for some antibodies in connection with ME, does not mean we have scratched the surface...

"A proportion had steps increased after trial - but in ritixumab a similar proportion also seemed to have been helped, which was then shown to be placebo when it got to Stage 3." - We cant say that for sure for the people who got better in the treatment group, but obviously the people in the...

"The autoimmune part of Cfs is a beaten dead horse to me" - To you maybe, but we have barely scratched the surface with trying rituximab and looking for some specific antibodies we know of. "The placebo outcome for the phase 3 ritux trail was better than Cyclo now" - What do you mean by this...

Im surprised theres been so little talk about this publication, 9 people went back to studies/work, and then the rest of the responders might or might not have gotten a placebo effect/other bias, potentially pulling the sf-36 mean score down. I see so many ME/CFS-studies written about that goes...

It would be cheaper for her to talk to a good friend Same effect

Its kind of bizarre, many of the so called "cured" in the recovery groups that get advertised left and right, are not actually recovered but are still on benefits for.. Years. I mean thats even illegal lol

I mean, ill take ur word for it Jonathan, but when reading up on it before trying it, what made me decide to go for it was the very low death rate and mostly treatable infection-related side effects. The scary side effect for me was PML, but that mainly occurred when rtx was taken together with...

It is for sure not higher than 5 perc with CCC, im not gonna bother having a technical argument about this sorry.

Rituximab is a very safe drug taken in isolation (not with other immunosuppressives), contrary to what many claim here. All the serious adverse effects in phase 3 were treatble infections and gastrointestinal events. To put things in perspective the placebo group had around 16 SAE`s and the rtx...

I dont know how u can reach the conclusion that "They were mildly improved at best" after reading this study I mean look at the graphs https://www.frontiersin.org/files/Articles/502145/fmed-07-00162-HTML/image_m/fmed-07-00162-g003.jpg Any of those jumps for me in functioning level would be...

Yes 5 percent has been the mean in the studies looked at (not after strict criteria,), the systematic review being one of them. Im not claiming it is correct or anything but I know for a fact its not higher, hence why i used it for the sake of argument here.

We dont know what the placebo rate will be next time though, it seemed unusually high for me

I dont disagree that we have to look at the results with great caution, but I dont think it is very likely that the study had so many patients that were undergoing a slow gradual spontaneous improvement. All research (not with canadia criteria mind u) suggests that around 5 percent undergoes...

5): Multicenter phase 3!

"Although the double blinded RituxME trial showed no significant differences between the rituximab and placebo groups for the outcome measures (35), there may still be a subgroup of ME/CFS patients that have an autoantibody-mediated disease where only few patients have autoantibody-production...