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Ufortunately I have lost trust in OMF. I hear more talk than i read research, and ultimately that is all I can judge them on

Why on earth would they include patients who took antidepressants. That clearly makes the results highly questionable

maybe it was halloween

Not sure, they said so in their new published hypophesis. Not sure if they specified

Just wanted to add: Fluge & Mella recently hypophezised ME might be driven by autoantibodies to g protein coupled receptors.

Maybe because we ME-patients work out metabolically all day he he

Interesting, I just found out via test that I have low xanthine. is that the same as hypoxanthine?

Nice, that dampens my worry significantly.

I dont know these guys other than Shepherd, are they all against GET and CBT?

Thats concerning tbh

It might be statistically significant, but the increase in meters does not seem to be imo. Having this as the only outcome makes results too susceptible to bias as people will overperform

This part surpised me however: "We speculate that cognitive techniques, which are reported to help subgroups of patients, might act by modulating the sympathetic output. If so, one would expect a greater benefit for patients with less ongoing immune activation and less vascular dysregulation...

One of the better hyphophesises ive seen presented on the field. Clearly explained, and with concrete treatment suggestions. Regardless of it being correct or not this is what science should look like

Well they might support their hypophesis if an phase 3 of cyclo has effect, or any anti-CD38 shows any promise, maybe in combination with anti-CD20

Should they not spend the time finding out what Fibromyalgia is, instead of treating rats based on hypophezised disease mechanisms? Just seems like a waste of time and money to me.

Its the same shit in different wrapping, and it was prior to Landmark getting as involved as she ended up being, and the issue with royalties is one of the reasons why they called it an "3-day-intervention" in the new project.

Thanks for the update, hope you keep improving @jonathan_h

There are shades of grey when it comes to economic interest though, and Live Landmark is obviously way over the line in terms of earlier income

Its a strong ask, but I think it would have proved a lot with PEM and could even be THE study to refer to when someone propose graded exercise. Im sure someone would agree to do this to forward the field. I probably would honestly

Agree! I suggested this too when i did a summary of this study