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This. And it's so sad :(

I agree, DecodeME is going to be fascinating! Glutamate, glutathione, cysteine and mitochondria is very interesting as well, especially for a nutritionist/cell biologist :D

But glutamate is not very specific. It can also be affected by lifestyle factors like diet and activity levels. Excitotoxicity is also linked to suicide ideation, psychosis, major depression, autism, I guess cognitive impairment (can't remember) and the whole glutamine/glutamate relationship and...

This makes me happy :) Well done everyone involved!

I only read the abstract and some parts of it so I might have missed the causal part. Let me rephrase, in -omics I've repeatedly been told the fold change is arbitrary, >2 is nice but 1.5 might also be used as a threshold. Below that you're left with the "significantly different but hardly...

I do this as well.

Same. The uncertainty is hard.

I'm worried about this as well. when I am able, I am active. Who knows what that does to the body, but not being active doesn't feel right either. It feels so good to MOVE. When I was hospitalized at the beginning of my illness because I was barely able to walk, the feeling when I started to...

But they're not saying BDNF causes the symptoms, only that it can predict them? Would you expect the same fold change in that case? A threshold of two is as arbitrary as 0.05 is for p values. Methylation of exons is interesting, I think in my genetics course it was brought up in regards to...

I reread the protocol, they do not mention NAFKAM anywhere, as NAFKAM has raised concerns about the safety of LP you'd think this would be "relevant information".

It's also interesting how they cite FITNET in the introduction, but not the long term follow up data that showed the effect wore off/the griup that didn't receive CBT had similar rates of "recovery". It's the same with PACE, they cite the 2011 paper, not the one that showed similar rates of...

Are you telling me it's not true that if I eat x hazelnuts a day I can expect to live x years longer (up to sixteen years)?! Nutritional studies are super clear that this is the case! Just don't ask too many questions or think too much about how those results came to be :whistle: Okay, so I...

The complement system are molecules that complement the immune system. They can bind to cells/microbes and act as targets for the immune system. Some of them can kill cells/microbes on their own.

I would love a prospective study like this! :thumbup:

I agree with you there.

Sadly, that happens. We are trained to think of obesity as a problem (not to say that it's not, but sometimes it can't be the focus), and this shines through in a lot of papers. Here they should have just focused on the fact that a HF diet can alter the microbiome, no matter your weight this...

Same amount of sucrose and lard in the chow. I guess it would be called "highly palatable" and is designed to get the mice/rat obese quickly. And yes, it's very artificial, although not completely valueless. There are, unfortunately, many people who eat nutrient poor diets high in both fats and...

They used this one: https://researchdiets.com/formulas/d12451 , fat nearly all lard with the rest being soy. Now, I don't mind a bit of animal fat or saturated fats, but they seem to increase LPS translocation from the gut to the bloodstream more than unsaturated fats do, which could increase...

Looking beyond the problems with mice models, there are many dietary components that can influence the effect of a "high fat diet". And a HF diet is not a necessity for obesity.. But I of course support the notion that diet should be part of treatment plans, it is a saly overlooked factor by...

I also have an interbal startling response. It's more pronounced during PEM.