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Good luck Daniel! Appreciate the attitude of not just doing the steps but making sure they matter.

Some screenshots from the game. Note that there's no clock ticking when you're filling up the bar so you don't know if you're going to make it. Here's how the bar looks before you fill it up. This is it about halfway full.

Ooh, you can play EEfRT on your own computer. https://www.millisecond.com/download/library/v6/effortexpenditureforrewardtask/effortexpenditureforrewardtask/effortexpenditureforrewardtask.web requires download and I am not guaranteeing it is virus free but I downloaded it and my computer still...

Got a reply from Treadway on EEfRT. He seems suitably cautious about the utility of using it in this population. Hi, Sorry for the delay. The task has not been specifically validated as a measure of fatigue. My understanding of the paper is that they are trying to understand the clinical...

I feel satisfied that I understand the test fails on 3 levels: 1. It is conceptually inappropriate to use in mecfs, a physical disease where effort preference isn't a legitmate scientific question, and in which the test hasn't been validated 2. The high failure rate of ME/CFS patients on hard...

1. My memory of this research program is they brought each patient in sequentially. Each person was at nih for around a week, one after another. (Which is why it took so long). Somebody way upthread was pondering this too but there's no way for subjects to speak to each other irl. 2. Because...

My reading is that the oil mostly comes from "dogfish" which is the shark they use for fish and chips. Apparently they're catching these fish anyway, they're pleased to be able to use the livers for something. What's more 25% of the weight of the shark is liver. Happily, dogfish is not...

Peroxisomes help make plasmalogens. A plasmalogen shortage is one of the findings by Lipkin. Also one of the theories in this hypothesis paper from Canada...

This paper has been extended by Che, Lipkin and Fiehn here: https://www.s4me.info/threads/bayesian-statistics-improves-biological-interpretability-of-metabolomics-data-from-human-cohorts-2023-brydges-che-lipkin-and-fiehn.27730/#post-496038 They bundle the results of their paper with...

There's history and precedent of booting out the data of people who try to maximise their payout, as shown in the next two screengrabs. This should be evidence EEfRT is a mess. But in terms of a fight over whether HVF's data should have been excluded, it's likely to weigh on Wallitt's side. It...

Here's a chart of hard tasks chosen (% terms) vs expected prize money (2x the mean of the prize awarded for tasks completed). We can see HVF is an outlier in these terms (top left in blue). PWME shown in red. If this test was really well-designed you'd expect the points to form a tighter...

While the exclusion of HVF's data is an outrage (he isn't even an outlier in terms of hard tasks chosen, all players played hard more often when the prize was high so his strategy isn't odd, and losing the easy tasks doesn't affect the primary endpoint) I agree choosing that battle is like...

I did email Treadway, back on the 22nd of February before I'd even dug in much. Hi Michael This new Nature Communications paper from a big NIH working group uses your effort metric and it ends up being a part of their conclusions. https://www.nature.com/articles/s41467-024-45107-3#Abs1 Does...

Above I posted a chart of Healthy volunteer F and their button presses. Below is an equivalent chart for all participants, which shows two important things. 1. Several participants lose easy tasks at various points, possibly deliberately (look for short red bars). Healthy Volunteer B and...

Healthy control F matters a lot. They chucked his data, but what his data shows is that EEfRT is a joke. To understand why I'm going to ask you to Imagine a lottery... 1. ... you will win two prizes drawn from a barrel. This is a pretty great lottery, because you choose the prizes that go in a...

I've been looking at this data for a few days now and thought I'd make an account here to post some of the things I've found. First, each participants choices on a chart. I placed a dot high to show a hard choice (Hard on y-axis), low to show an easy choice (Easy on left axis). The top left...