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um, you know what, i think maybe it was benjamini hochberg. yep, they mention that. I mis-remembered.

While we are talking about statistical intuitions, I find adjustment for multiple comparison to feel very weird. You take a bunch of p-values and just multiply them by a big number. It's effective at making lots of possibly significant results go away. Lot of bathwater gets thrown out and an...

I share this piece because I suspect some researchers are getting excited by AI. I don't think it's anywhere near being generally useful yet. Of course there might be tasks where it can be deployed really usefully. In my own line of work it is incredibly useful at transcribing audio, for...

https://www.understandingai.org/p/i-got-fooled-by-ai-for-science-hypeheres I got fooled by AI-for-science hype—here's what it taught me I used AI in my plasma physics research and it didn’t go the way I expected. Nick McGreivy May 19, 2025 In 2018, as a second-year PhD student at Princeton...

Montreal Cognitive Assessment = MoCA. 54 patients, 30 controls. I'm feeling the post covid brain slump myself. I usually do a few word games before bed and after having covid a couple of months ago I'm not doing well at them!

If we did do this we should specify in advance what the intent is? Perhaps it could have three sub-goals: 1. determine feasibility of self-capillaroscopy. 2. get a rough feel for the extent of peculiar looking capillaries in a self-selecting, unblinded pwme population. (is there an ai you can...

Here's my beginner attempt, just as proof of concept before I try to improve: Methods: one human pinky finger, one digital microscope, one dab of oil (canola!), one smartphone to take a photo of the digital microscope screen, one assistant to hold the microscope stable while I used the...

This looks interesting: muscle fibre types. If we look at panel C we have pre and post bed rest (pre is white, post is grey). There's not much movement in the four fibre types. rest doesn't seem to change their composition. But in the final chart of panel B we see controls, long covid (red) and...

Those are standard error bars not standard deviation bars. sd tells you about variation in the sample, se tells you about variation if you drew a bunch of samples from your sample. Those graphs are clearly made in excel and I believe excel does standard error as the default!

Yes, diabetes has microvascular abnormalities visible on capillaroscopy. Apparently diabetes includes a lot of "connected" vessels, which reminds me of the idea of "shunting" which David Systrom has raised. So it is unlikely this test would reveal patterns unique to me/cfs. What it might do...

Anecdote is a funny word. It simply describes a person saying what happened. But is loaded - it conveys an absence of rigour, often suggests the story comes from an uncontrolled situation, and is possibly second hand. An n=1 self trial will lack sample size and institutional oversight. It may...

for anyone else who also doesn't know Tom: Tom20 is a protein that plays a crucial role in mitochondrial protein import. It's a receptor on the outer mitochondrial membrane that recognizes and binds to mitochondrial precursor proteins with a presequence, facilitating their translocation across...

Can I ask a few questions about malate: Would it be used when a person is in ketosis? Does it have have a caloric value of its own or is it considered as a catalyst/co-factor for burning energy? Are there any substances that might be used disproportionately a) when relying on malic acid or b)...

Ankush Dehlia has a review paper published with Mark Guthridge (thread, abstract below). Guthridge is not actually the researcher to whom the TCR funding went. (That's Ken Walder, who is at a different Deakin campus). Perhaps Dehlia is working with Walder but they simply didn't co-author the...

Cerebral flow is probably the core issue in POTS and without measuring that you're measuring compensatory effects. Arguably the HR boost is the body trying to get blood to the head.

This looks like a really easy test, they push a microscope against the bit of skin where it joins onto the fingernail and take photos of the capillaries https://www.sciencedirect.com/science/article/pii/S1521694223000359 Would be great to have this test tacked onto any future metabolomic /...

I'm always interested to see theories where LPS can trigger PEM-like symptoms. I have poor digestion and often digestive disturbances can leave me exhausted and very brainfogged. I've come to think of that as leaky gut pushing LPS into the blood. Duration is usually not as bad as PEM from...

After a long time of not having much sign of mcas, I apparently now have a pretty bad histamine intolerance. I get red rashes and itchy welts, I have sores on my face, and my digestion goes to absolute heck if I eat high-histamine foods. It's an extremely unwelcome development on the food side...

Two reports from me: 1. Turns out I just love sumac? I never knew what it was or what it tasted like, assumed it was a spice like cumin that needed cooking. Now I know it's just a dried fruit. I am putting it on everything! I've always been a fan of tart flavours and it's delicious. 2. I got...

I wanted to post a few recent UPR papers I found (recalling that the UPR could be tied into the ER stress Hwang found and that the wasf3 goes from the ER to the mitochondria) 1. This one caught my eye because we seem to hear about extracellular matrix, actin and fibroactin so much these days...