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  1. Andy

    What (maybe home-based) useful new research could be done using the DecodeME cohort?

    That is the back-up plan assuming that we can't find a better solution. And yes, contact details are stored to enable recontacting when appropriate.
  2. Andy

    What (maybe home-based) useful new research could be done using the DecodeME cohort?

    Continuity. It would need somewhere where the data can be stored, and people to process any application and distribute the data. At the moment it is stored on servers at the University of Edinburgh, there is a data access committee to review applications, and UoE staff who can process successful...
  3. Andy

    Cognitive Workload During a Sustained Visual Attention Task in Middle-Aged and Older Adults With Persistent Symptoms After a [mTBI] 2025 D'Silva et al

    Abstract Background Individuals with prolonged symptoms after a mild traumatic brain injury (mTBI) report requiring more effort to complete complex and sustained activities. However, the relationship between cognitive workload and patient-reported symptoms is unclear. Objective To compare the...
  4. Andy

    Functional cognitive disorder in Alzheimer's disease 2025 Cabreira, Stone, Carson et al

    Highlights • Functional cognitive disorder can occur comorbidly with Alzheimer's disease. • Clinical clues may identify patients at risk of converting to Alzheimer's disease. • This study has implications for management, prognosis and research trials. • We propose potential mechanisms which may...
  5. Andy

    Associations between emotional awareness deficits and somatic symptoms in a community and clinical populations: a cross-sectional study 2025 Kang+

    Abstract Background Deficits in emotional awareness may contribute to the development and maintenance of somatic symptoms. This study explored emotional awareness deficits and their association with somatic symptoms among individuals with a high somatic symptom burden from an online community...
  6. Andy

    Preprint Population-scale sequencing resolves correlates and determinants of latent Epstein-Barr Virus infection 2025 Nyeo et al

    Abstract Epstein-Barr Virus (EBV) is an endemic herpesvirus implicated in autoimmunity, cancer, and neurological disorders. Though primary infection typically resolves with subclinical symptoms, long-term complications can arise due to immune dysregulation or viral latency, in which EBV DNA is...
  7. Andy

    Heightened protective decision-making related to physical, but not cognitive, effort in individuals with fibromyalgia, 2025, Herman et al

    Highlights • Individuals with fibromyalgia require higher incentives for physical effort tasks. • No differences in cognitive effort task between fibromyalgia and control groups. • Fibromyalgia participants display increased willingness to wait for rewards. • This suggests higher...
  8. Andy

    Neuropsychological aspects of the patient’s personality in the context of psychosomatic experience, 2025, Krause and Forgon

    "Our findings reveal that the most frequently reported psychosomatic symptoms are fatigue, back pain, a bloated stomach, and headaches. These physical symptoms often lie at the intersection of psychological and somatic factors, which largely accounts for the manifestation of psychosomatization...
  9. Andy

    Neuropsychological aspects of the patient’s personality in the context of psychosomatic experience, 2025, Krause and Forgon

    "In essence, fatigue, back pain, a bloated stomach, and headaches appear to be psychosomatic symptoms that frequently manifest, often in combination. This suggests that special attention should be paid to such symptom clusters during differential diagnosis, since, as Wise (1) explains...
  10. Andy

    Neuropsychological aspects of the patient’s personality in the context of psychosomatic experience, 2025, Krause and Forgon

    The primary objective of this study was to examine the relationship between personal variables, as measured by the NEO-PI-R, and psychosomatic symptoms, assessed through the PSS, from a neuropsychological perspective. The secondary aim was to evaluate the frequency of various psychosomatic...
  11. Andy

    UK: Medical Research Council: Centre to study how exposome causes chronic inflammatory disease

    "A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases. These include: asthma chronic obstructive pulmonary disorder inflammatory bowel disease Chronic inflammation-related diseases have been...
  12. Andy

    Vulnerability factors for pediatric disorders of gut–brain interaction and implications for functional impairment 2025 Beinvogl et al

    Abstract Objectives To evaluate the frequency and number of vulnerability factors for the development of pain-predominant disorders of gut–brain interaction (p-DGBI) in a well-defined cohort of pediatric patients and examine associations with pain severity and functional impairment. Methods...
  13. Andy

    Myasthenia gravis with antibodies against the AChR, current knowledge on pathophysiology and an update on... 2025 Martinez-Martinez et al

    Full title: Myasthenia gravis with antibodies against the AChR, current knowledge on pathophysiology and an update on treatment strategies with special focus on targeting plasma cells Highlights • Thymic involution, follicular hyperplasia and thymoma observed in AChR-MG are associated with...
  14. Andy

    Autonomic arousal and heart rate variability in functional somatic disorder - a cross-sectional population-based study 2025 Gormsen, Fink et al

    Highlights The BDS checklist score was negatively associated with autonomic arousal. Individuals with FSD, especially multi-organ, had faster heart rates, independent of sex, age, smoking, and activity. An increased sympathetic neural and neurohormonal activity in patients with FSD may be...
  15. Andy

    PBC-HOPE: A randomized controlled trial of hypnosis and psychoeducation in women with primary biliary cholangitis and fatigue 2025 Untas et al

    Abstract Objectives: Fatigue is the main symptom of primary biliary cholangitis (PBC), but has not yet been improved by any therapeutic intervention. This study evaluated the efficacy and safety of hypnosis and psychoeducation in improving fatigue associated with PBC (PBC-HOPE ClinicalTrial.gov...
  16. Andy

    "The impact of leading questions on ME/CFS research: bias and stigma in study design", 2025, Jason et al

    Full abstract. ABSTRACT Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex and often misunderstood illness, characterized by post-exertional malaise, unrefreshing sleep, and cognitive impairments. Objective To investigate how question phrasing in ME/CFS...
  17. Andy

    Feasibility trial of a self-help digital intervention for functional cognitive disorder, 2025, Cabreira, Stone, Carson et al

    Selected quotes. "While FCD may present in isolation, it is often part of a broader syndrome such as fibromyalgia or chronic fatigue syndrome.5,6" "Intervention Mementum was designed as a self-help app supporting the delivery of education about predisposing, precipitating and maintaining...
  18. Andy

    Feasibility trial of a self-help digital intervention for functional cognitive disorder, 2025, Cabreira, Stone, Carson et al

    Abstract Functional cognitive disorder is the cognitive subtype of functional neurological disorders. Symptoms are associated with a high level of distress and typically arise due to various risk factors including abnormal focused attention, high memory expectations and poor metacognition...
  19. Andy

    Breathing therapy for patients with medically unexplained physical symptoms and dysfunctional breathing: A pilot and feasibility trial 2025 Karlsen+

    "According to the scientific literature, DB patterns might be harmful, self-perpetuating patterns [14,20] and may partially explain some MUPS [18,21,22]. There are indications that its correction after breathing therapy combined with stress reduction and lifestyle management is associated with...
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