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Abstract Medically unexplained physical symptoms (MUPS) are symptoms without an identifiable organic cause that lead to functional impairment. MUPS is highly prevalent in general practice consultations. This pilot trial aimed to investigate the effectiveness and feasibility of a 5-week breathing...

"The abbreviation CFQ is commonly used to distinguish it from CFS. The scoring procedure of the instrument allows to differentiate between no fatigue and severe fatigue with an additional item to assess chronicity. According to Cella & Chalder [Citation22], the scale accurately discriminates...

"Physical (e.g. reduced strength), cognitive (e.g. lack of concentration), and emotional (e.g. lack of energy) fatigue symptoms may be distinguished [Citation4]. The persistence of symptoms for at least six months is considered chronic fatigue (CF). Different criteria and case definitions have...

Full title: Chronic fatigue: psychometric properties and updated norm values of the Chalder fatigue scale in a cross-sectional sample representative of the German population Abstract Background The Chalder Fatigue Scale (CFQ) is a commonly used self-report instrument assessing the severity and...

ABSTRACT Aim Chronic obstructive pulmonary disease (COPD) is frequently associated with skeletal muscle dysfunction, having a considerable impact on exercise tolerance and patient prognosis. Mitochondria play a role in skeletal muscle weakness and exercise intolerance in COPD, but the majority...

Abstract Brain function relies on energy supplied by mitochondrial energy transformation, but how cellular energetics constrain neurological function and cognition remains poorly understood. Genetic defects in mitochondrial DNA cause rare mitochondrial diseases (MitoD) that offer a unique...

Abstract Background Functional neurological disorder (FND) is a common neurological presentation with symptoms such as seizures, walking difficulties, limb weakness and cognitive difficulties. Treatments for FND include physiotherapy and psychological therapy. Eye movement desensitisation and...

"PPS, which include conditions like chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome, often co-occur with or resemble FND. These disorders can range in severity from mild to debilitating, significantly affecting patients’ lives and representing a large portion of healthcare...

"Persistent physical symptoms (PPS), also known as persistent somatic symptoms, are distressing complaints—such as chronic pain, fatigue, or dizziness—that last for at least 6 months and often lack a clear medical explanation (Kube et al., 2020; Löwe et al., 2024; Van den Bergh et al., 2017)...

Background: Persistent physical symptoms (PPS), including functional neurological disorders (FND), chronic pain, and other neurological conditions [e.g., Parkinson’s disease (PD), Huntington’s disease (HD), autism spectrum disorder (ASD), and psychosis], present substantial challenges for...

"The DAHLIA treatment (prototype version 1.0) consisted of 4 self-guided microsessions per week for a total of 24 sessions delivered over 6 weeks. Moreover, patients had weekly contact with a therapist through a 30-minute phone or video call. The digital intervention was offered through the...

Abstract Background: Recent research shows that chronic pain affects 27% of the adult population. For many, pain significantly impairs quality of life and everyday functioning. Behavioral interventions have shown utility, but access remains limited. Digital health solutions can increase reach...

No, I don't know, and honestly I would be surprised if he knew himself, given how much is going on at the moment.

Are any forum members aware of any other databases of genetic information for people with ME/CFS (however defined) in existence other than; UK Biobank Lifelines FinnGen Mass General Brigham Biobank Michigan Genomics Initiative Biobank Estonian Biobank Million Veteran Program Thanks for any...

In an ideal world who would you want to take notice of it? Especially who outside the current ME/CFS research field?

Two different explanations so far.....

From the article, Can anybody explain how these two things are connected?

Glucose uptake in activated CD4+ T cells is essential for increased metabolic needs, synthesis of biomolecules and proliferation. Although, facilitated glucose transport is the predominant route for glucose entry at the time of activation, here we demonstrate role for the sodium-dependent...

Abstract Background Medically unexplained symptoms (MUS) with pain are classified as somatic symptom disorder (SSD) with pain in the field of psychiatry, although an undetected biological basis may underlie at least some of these cases. One such candidate etiology is autoantibodies. Autoantibody...