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As the press release says, "It’s a 4 year project between Action for ME, Edinburgh University and the Genetics Centre of Excellence.". The membership of the board of the Genetics Centre of Excellence, which includes me, can be seen here. Severe patient representation for delivering the PRIME...

I certainly hope that those forum members who are able to will step forward to be part of the PPI pool.

Highlights BTNL3 binds directly and specifically to Vγ4+ TCRs via its IgV domain The superantigen-like binding mode focuses on germline-encoded TCR regions In contrast, γδ TCR binding to a clonally restricted antigen is CDR3-mediated Mutagenesis indicates parallels with BTN3A1-mediated...

"The overlapping symptomatology of long COVID with myalgic encephalomyelitis/chronic fatigue syndrome (ME/ CFS), a disease that has been described since the 1930s, allows us to extrapolate prior evidence to this patient population. Similar to long COVID, ME/CFS is felt to be a post-viral...

[All text converted from the available image at link below] The Centers for Disease Control and Prevention estimates that as of 2022, 7% of US adults are living with post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), also known as long corona- virus disease...

Abstract Background Patients with disorders of gut-brain interaction (DGBIs) presenting to specialist care have a high prevalence of psychiatric morbidity. Psychiatrists can provide effective treatments for these disorders; however, care is rarely delivered in an integrated manner. Aims This...

ABSTRACT Background Functional medical disorders (FMDs) refer to persistent physical symptoms that cause impairment or disability, but which cannot be explained by routine medical testing. Negative perceptions towards FMDs exist amongst a variety of healthcare professionals, including medical...

Abstract Background Functional somatic symptoms and disorders are common and complex phenomena involving both bodily and brain processes. They pose major challenges across medical specialties. These disorders are common and have significant impacts on patients’ quality of life and healthcare...

Abstract Growth and differentiation factor 15 (GDF15) is a significant player in cellular stress and energy homeostasis. GDF15 is elevated in cancer cachexia, chemotherapy-induced anorexia, hyperemesis gravidarum, and mitochondrial disorders. Here we analyze GDF15 in anorexia nervosa (AN), a...

Highlights • Somatic symptom and related disorders were common in the neuroimmunology clinic. • Functional neurological disorder and somatic symptom disorder were the most common. • Patients with SSRDs were older and more likely to be white than patients with MS. • Working in health care and...

Full title: The role of illness perception and behaviour in the treatment of adolescents with multisystem functional somatic disorders: a post hoc mediation analysis of the AHEAD trial ABSTRACT Psychological interventions can reduce symptom load and disability in adolescents with various...

Abstract The circadian-regulated transcriptional repressor REV-ERB-α is a key mediator of skeletal muscle oxidative capacity, enhancing exercise performance when activated. Conversely its global genetic ablation leads to impaired performance. Simultaneously the kynurenine (KYN) pathway...

So, yet again, the effect is most likely to be in how much the 'education' manages to change how people answer questionnaires.

Abstract Objective To determine the effect of education programs on fatigue outcomes in people with neurological conditions. Data sources MEDLINE, CINAHL, EMBASE, PEDRO until May 2025, according to PRISMA guidelines. Review methods Systematic review with meta-analysis of randomised controlled...

Abstract The 5th International Symposium on Regulatory Autoantibodies Targeting GPCR (RAB-GPCRs) advanced the understanding of the significant role played by autoantibodies targeting G-protein-coupled receptors (GPCRs) in various human diseases. Once considered passive markers, RAB-GPCRs are now...

Are all illnesses that involve the immune and neurological systems labelled as neuroimmune? Are there any that aren't? And if so, why not? I've tried investigating this myself and the information that I can find is vague and unsatisfying, so I'm hoping that the S4ME hive mind can help out here.

Proper scientific methods? That obviously puts unfair pressure and expectation on those who have built up careers not using them. /sarcasm

Coverage on Radio 4 starts at approx. 1:22:40 https://www.bbc.co.uk/sounds/play/m002dlgr

From an email from AfME, latest fundraising campaign. https://www.actionforme.org.uk/support-us/donate/