Search results

It is tactical ambiguity. Things are defined so that multiple interpretations can be made, even opposing ones. Then you can pretend to have a theoretical framework without having to admit that you don't have one, and say whatever is convenient at the time. The lack of clarity will be carefully...

Fascinating. My impression from studying genetics as amateur is that what looks like a hyperinflammatory disease on the outside often has at its basis an immune deficiency and this appears to be the case here as well. It sounds like this is big news for many patients, not just the ones with...

After longer walks, fatigue and weakness set in within seconds as soon as I slow down or stop. This seems like something that could be related to abnormal ion channel function. The effect for an outside observer would be striking. A person that just walked at decent speed without apaprent...

Is this why periodic paralysis and similar presentations appear to be overrepresented among ME/CFS patients (although reliable data is still lacking)?

The symbol for the citrate synthase gene is CS. That could be the one he talked about.

Thanks @BrightCandle. I wasn't able to watch this event. Did he give any details on what mutations were found?

If the nervous system is infected at multiple locations, could reactivation in one location without reactivation in other locations explain the fluctuations in symptoms, with appearance and disappearance of symptoms?

This bot seems better than humans in a lot of situations. Or at least not worse, and faster.

When a person attempts to convince me of an idea, and goes back a hundred years to quote some authority, the effect is not persuasive. It makes me ask where the evidence from today is. After all a hundred years have passed, which should be more than enough. I'm not doubting that people are ill...

My impression is that the quality of the average paper has increased a lot over the last 10 years. But the recent paucity of papers coming out is noticable. Unutmaz has something to publish, and the NIH studies should also come out soon. Then next summer DecodeME. I'm not sure what Unutmaz...

Build and maintain green spaces that are safe, pleasant to be in and clean instead of crap like this.

Does anyone know more about this study? From the description it sounds as if the change in endothelial function is seen quickly, unlike the 2-day CPET where a delay of 24 hours is required to see changes on the second test. This would make repeated EndoPET with exercise in between a superior...

Nice find.

I think of lack of energy as the main problem, and that most other symptoms can be explained as resulting from it. It is not constant severe fatigue, but fatigue plus various other alarm signals and dysfunctions, often fluctuating, with abnormally fast and deep deterioration in response to...

Can you imagine the sheer stupidity of people who think "learning to feel tired" is a good way of thinking about a life-destroying illness? Not to mention that we have a pretty good idea how "unlearning the illness" works as treatment approach because that's very similar to the CBT/GET...

Apparently some people need to believe in the lie that they can control the illness with their mind. And they want to tell themselves the most inspiring story possible, and they seek confirmation and approval for their views from others (as well all do). So they want to tell a dramatic story...

It's exciting that this is a muscle biopsy study. We need more tissue studies.

I think it's possible to try too hard to accomodate people who are not interested in reality. In a sense we all want the same thing, but the LP promoters aren't interested in dealing with reality (and that's also why they'll never be able to find a solution). They're more interested in telling...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8657997/

I also don't think harms and benefits should require equal evidence. Human psychology and business interests are strongly biased towards a treatment being effective. It's much more difficult for harm to be noticed. If there are consistent reports of harm this needs to be taken far more...