Search results

I feel hope clashing with scepticism here. A new highlight notice with a strong focus on biomedical research and mandatory(?) requirement to bring in researchers new to the field is a positive sign. But it won't be enough, in my view. The previous highlight notice wasn't so different and has...

i’ve checked and that UK study didn’t go ahead (at least not with a funding source I’d heard of) so the only other study around is the Watanabe one. There’s always a lot to be said for replication by a completely independent group as in this case. However the other study is vast (120 subjects)...

This has me slightly mystified, but looks like a large-scale replicatioin of the brain neuroinflammation study that caused such a stir back in 2014: First Direct Evidence of Neuroinflammation – ‘Encephalitis’ – in ME/CFS 120 is an enormous sample size for a PET study - a good thing but also...

This thread Suggests that the planned pilot study might be redundant because a much bigger study is in the pipeline: https://www.s4me.info/index.php?threads/development-of-surrogate-end-point-biomarkers-for-chronic-fatigue-and-myalgic-encephalmyelitis-chronic-fatigue-syndrome-me-cfs.965/ It...

Well, certainly a very worthwhile approach but a pilot and only 7 mecfs and 7 MS patients makes the conclusion somewhat overblown I’m willing to bet they didn’t correct statistics appropriately for all the many comparisons, which might do for the stat sig results. Above all, we know that...

Good question. In my view we only reached the start line for biomedical research a few years ago and there has been some structural progress since, attracting new researchers and a gradual increase in funding and interest, but certainly no breakthrough as yet. Which isn’t too bad in that...

Briefly: Roerink et al argued that methodological issues with blood plasma processing could account for the finding of higher cytokine TGF-beta in patients. Montoya et al responded that they looked at blood serum, not plasma, as their paper had spelt out. Whatever the motivations behind the...

Nice post :) Do you know if she also presented data for B-cells and NK cells? What’s really interesting about this work is that her group are using Seahorse technology too, so should be directly comparable. The finding of using less of maximal respiratory capacity is potentially slightly...

The authors specifically said that was something they were considering.

The technology behind the new study finding (above) that cells from mecfs patients can't ramp up energy production Here's a bit more about the Seahorse technology and what it measures, using info from the Seahorse site. First off, it's looking at the body's two main energy pathways, glycolysis...

I suspect part of the problem here is that the sample for controls (N= 12) is so small, too small really. I think statistical theory says you need at least this number, probably a few more to have a chance of a representative sample. I think you would know better than me. Thanks! It will be all...

My first post here :) Thoughts on: Cellular bioenergetics is impaired in patients with chronic fatigue syndrome My notes from reading the full paper. This looks like an important contribution to the growing field of research probing problems in producing energy in mecfs. These preliminary...