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It is, thank you. I think I understand the key metabolic ideas more clearly. Though presumably the central question for any theory to answer is, “how does this cause ME?“ And as you say, this is where you rely on speculation to bridge the gap. I will bow out at this point, but thanks for taking...

Thanks. I was hoping for something more succinct because of my brain fog. From a quick scan of your other post, malate seems to play a central role, but I wasn’t sure if the underlying issue was presumed reduced Mitochondrial reduction of NAD(P). Can you sum it up in a couple of sentences?

Thanks. Presumably, there are vast numbers of possibilities as to what has gone wrong in ME/CFS (I've been reading research papers for 30 years and have come across more than a few). What makes you think this is the answer, and what evidence is there currently? And how would you test your theory?

I'm not sure we have robust data on asymptomatic infections causing LC, given the very broad definition of LC and whether asymptomatic infections lead to LC that is ME/CFS. There is quite a bit of evidence that people with no serological sign of Covid later developed LC-like symptoms, though as...

@Jonathan Edwards mentioned that mental exertion uses little extra energy, so it probably doesn't fit with thinking triggering PEM through simple energy demand. In a nutshell: normal walking burns over 200 calories an hour. Thinking uses maybe 10 calries an hour. Some figures from this BBC...

I think a common experience is that PEM feels the same where it was triggered by physical or mental exertion. I guess one possibility is its mitochondria overload in the brain or in muscles, but perhaps Exertion in either organ (Muscles, cancer or organs, collectively) trigger a more generalised...

The problem with the faster drop in grips strength for me/CFS versus healthy controls, is that something similar is seen in a number of illnesses – it’s not specific. The CPET studies do you see more unusual, but there’s very little comparison data. I believe the one consistent effect is in...

I’m not quite sure what you want with your prevalence citation, but this Louis Nacul in study is interesting based on the British Columbia population survey. 1.1% people self reported CFS, but only a third of these of these met questionnaire-assessed criteria. > The population prevalence rates...

Good grief: clear reporting of a negative result, including that it contradicts earlier positive findings. That might seem like a backward step, but I think it’s huge progress, not least because Arnaud Germain is an impressive researcher from a big group (Maureen Hanson’s)

Thanks. If my maths is right, 20% said they improved with CBT and physical function. So overall, it’s modestly unhelpful, compared with a GET, which is very unhelpful/harmful. and that’s consistent with other surveys – at least according to my rather unreliable memory.

That’s interesting, but inevitably biased since people who did well on it are far less likely to find the survey. What were the comparison figures for CBT/other stuff? A comparison with other treatments is probably more useful.

Looks like they do have some interesting data for Persistent Lyme disease, but the samples are too small annd the ME cases are meaningless given those selection codes. Also, it is super easy to get false positives (or very low P values near significance) due to artefacts in the Data and even...

This isn't the main finding, but this MRI on a subset of effort preference participants while doing handgrip (I think) is very interesting and received v little attention. Though based on only 8 peeps, IIRC, so not much to hang our hat on.

Bear in mind that an AUC = 0.5 is what you get from a coin toss.

It would be interesting to know what impact the menstrual cycle has on symptoms in other illnesses.

I fully agree with that, largely because of the excellent analysis you’ve done show that other medical charities fund a big proportion of the research that happens, and I believe that helps open the coffers of the funding organisations. The gift aid (charities reclaiming tax already paid on...

and this puts an enormous question mark over the study. The highest credible prevalence rates we have for ME/CFS, from the recent Samms/Ponting study, is 0.6%. Seems hard to believe they found the same rate of NEW cases a year in the non-Covid control group Something doesn’t add up. You would...

A single cell RNA study from Andrew Grimson, Germain? (Maureen Hansen group) highlighted monocytes as one of the cell types difference between people with me and healthy controls. I’m not sure if monocyte differences were baseline or pre-/post Max exercise. Sorry, I’m in no state to find links...

Seriously impressive digging again on here. I’m afraid I can’t help, to pass on a couple of things Chris has mentioned to me in general. First, because UK buying bank data is so accessible, it’s used in a lot of GWAS Studies, and some of these are of questionable quality. Second, Mendelian...

personally, I think a charity the size of the ME Association should be working through its staff primarily, with trustees providing oversight. At the moment, the trustees appear to be micromanaging the charity and making all significant decisions. I’m sure that was necessary when the...