Search results

Maybe a more succinct response would be.. Maybe more people get better or are asymptomatic in some way so we don’t record them as having ME/CFS. But when we know more we’ll find they did have this same thing but something took a different path. Like, loads of people get Flu but only some get...

That’s true @Trish It was part an idle counterpoint. So maybe not worth thinking too much about. But I suppose I was also thinking about self selection. We’re the ones that don’t get better. I guess that’s what ME/CFS is but maybe that’s not all it is? We know people get better earlier, we...

Physically and mentally exhausted. But my body and mind are somehow not restful (I’m cautious to say not relaxed but that could describe it too, or maybe alert, primed) while awake or asleep, with sleep being difficult or broken/lower quality. Exhausted and restless may be another useful...

A trivial but recent (and common) example. The effort of sitting up and trimming my hair or beard with clippers. Sometimes it goes okay, other times it’s too much and a few hours later I can feel the heaviness and aching spreading through my whole body, not just arms or core that had been used...

I also used some Deep Research summaries and Audio Generated summaries from Google Gemini, happy to share these too although I understand there are mixed feelings on ethics and accuracy of these.

I’ve been reading/listening to lots about the immune system, particularly B and T cells. And thought it may be worth sharing some links to info I’ve found useful. If others have useful resources please chip in! There’s a lot of sources here and duplication, I found reading/listening to...

That’s a great way of putting it @Kitty and I absolutely agree that things which may on the surface look it, don’t necessarily contradict each other.

What if we’re the rare ones and those recovering or switching are the norm? We don’t really have the data to say which way round things are. Or if people ‘recover’ without ever having been bad like us. Maybe we all had something for years before we thought we did? The idea of a permanent...

That they’re developing a remote platform and using tools like the Ouura ring and GripAble device are interesting. Being able to have remote studies and gather information will I think be important to running more studies more efficiently and involve people who are housebound. But the solid...

It was a generally interesting science story but the added elements of genetics and evolution ‘finding a way’ and doing unexpected things along with the metabolic and possibly future links with disease mechanisms made me think others here would be interested.

There’s also an article about this https://www.vanderbilt.edu/evolution/castiglione-lab-discover-horses-run-faster-by-ignoring-an-ancient-mutation-that-says-stop/ And it was discussed on this week’s Science in Action in the BBC World Service https://www.bbc.co.uk/sounds/play/w3ct5vfb

Science. (Accepted): Running a genetic stop sign accelerates oxygen metabolism and energy production in horses Castiglione, GM, Chen, X., Xu, Z., Dbouk, N.H., Bose, A., Carmona-Berrio, D., Chi, E.E., Zhou, L., Boronina, T.N., Cole, R.N., Wu, S., Liu, A., Liu, T., Lu, H., Kalbfleisch, T., Rinker...

Okay the last of my collection of posts from recent weeks and reading! Thanks for everyone’s indulgence. Sorry it’s been more of a brain dump than a discussion. Big questions for me around the findings seem to be… We don’t seem to know where in the system or B cell lifecycle this change or...

To revisit the discussion of pathways, triggers, complexity, and concerns over disease categorisation I thought I’d give an example from software development. In a simple software bug, someone performing certain steps will cause a particular problem to occur. This is reliable, repeatable. The...

I’m sure we all look forward to hearing more on your thoughts! And I really like the reminder that nature finds ways of doing things, which we often miss trying to look for logical or efficient paths or patterns. I like Hutan’s idea of people with higher levels being more ‘protected’. I also...

I wondered if the hand grip strength results seen in ME/CFS had been repeated for LC, a quick search turned up this https://www.nature.com/articles/s41598-024-52401-z

Thanks that is interesting. So a sort of fingerprint and then that varies with various diseases? interesting thoughts on evolutionary selection over time and up regulation too.

Maybe going a bit off topic but I’ve been interested in how significant my response was to the covid-19 vaccines and often wondered if there is something to be learned here. Largely because of just the way I used to work troubleshooting problems in large complex computer systems. If you have...

Thank you @Yann04 and @Wyva for sharing your memories, and the link! It looks interesting, I'll listen later. Some questions/thoughts. I'm not specifically directing that anyone or even expecting answers! Why would here be a skew towards IGHV3-30 gene usage? My understanding is VDJ...

One thing I’ve particularly enjoyed is papers which I’ve gone off and learned about the background and science involved in more detail. It can take many months. Picking up bits and revisiting and re-listening to papers but it’s really interesting. I’m just starting to understand bits about B...