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Could it just be the effect of age here or did they account for that? Presumably those who were pregnant were younger and the difference looks similar to the age ratios?

And a write up on Arstechnica https://arstechnica.com/science/2025/01/how-sleeping-pills-interfere-with-the-brains-internal-cleaning-mechanism/ I was also pondering potential ME/CFS relationships too. Either something disrupting norepinephrine and this process which triggers some symptoms or...

Having read the rest of the thread I think the answer to my question is somewhere between ‘yes’ ‘lots of potential reasons’ and ‘it’s complicated’…

Sorry if I’ve missed this, still getting my head around the thread, but why would the ratios of these be different? One type being overproduced or the others underproduced? Or over or under-consumed?

I understand the reasons for means-testing, but the way so many systems are set up drives people into poverty before they can get help and then keeps them there. A Social Care is another big problem in the UK. For something which is supposed to help provide security, for it to effectively remove...

Yeah, it’s the difference between research and treatment too I think. Most of us have access to and interactions with health services, which are really treatment services. Investigations performed are just to find which predefined path we are put on, not to understand something. If there isn’t a...

I have zero information on this but I would be 99% sure it’s government/institutional. Most UK research linked to universities is I think government, national academies/institutes, european commission, etc. There’s sometimes charities involved too but individual donations seems much more a US...

I found this an interesting article from a science writer for Our World in Data. Rather than the usual hype it focuses on five treatments which showed high degrees of efficacy in phase 3 trials published in 2024, so are being or close to being used and having a real impact. There’s also audio...

I’m only recently teaching myself this stuff, biology also wasn’t my thing educationally so I may not be right but… This paper is I think more looking at two different analysis techniques (GWAS and rare variant/loss of function burden tests) than partial or full genome sequencing. You can do...

This isn’t something I’m an expert on, but with a £7 million cost I expect the target will be institutional/government funding. And while there may be a mix of funding sources, anything attempting to combine those with commercial services would I agree get very difficult in terms of ethical and...

This looks really interesting. So good to see Chris, Sonya and others working together on the next steps after DecodeME. I’m sure the trials and application processes have taken a lot of time and effort. And thanks to @Chris Ponting for the links to the paper and info on other uses of the...

Read this email earlier, all really good stuff to hear. The numbers involved, the DNA data having been processed, extra questionnaires. The work involved must have been massive. Thanks to all involved. Now the hopefully fun bit for the science team!

I can get a delayed PEM response from sitting at a sink and washing my face. Or raising my hands and using clippers to cut my hair (even if lying down). Or having a conversation. Or… you get the idea. Sometimes there’s immediate effects too. Sometimes not. But none of these are ‘exercise’ and...

Absolutely agree @Kitty I’ve been reading (listening to) the paper some more and made some notes… On the one hand I’m not sure this can be related to PEM because of their definition of exercise and exerkines. I can get PEM from minimal activity which certainly does not meet their definition...

I suppose you could say it’s caused by exertion more than exercise? But even that isn’t telling the whole story and it’s certainly not a 1-1 relationship. But there could be something whereby some of the things produced by activity are sometimes involved in something going awry. From the...

The problem is then that probably becomes a disincentive for private companies to run trials. Or at least they will say it is and/or threaten to run trials elsewhere and so governments won’t push for it. I don't think there’s a reliable way of forcing companies to do this. Other than taxing...

Really interesting. I remember Demis Hassabis talking about how AI/ML is well suited to problems with large search spaces (AlphaGo, AlphaFold) and how the he hopes it could be the language of biology in a similar way maths has been for physics. AlphaFold seems to be finding uses as part of...

It seems a shame people are criticising the primary outcome measure and study design after the fact. But I guess some people had invested their hopes in this? That would be interesting. Publication would really help, in terms of potential for understanding mechanisms but also to help those...

That’s good to hear. Thanks for the context. Much as propagation/repetition of misinformation about ME/CFS obviously annoys me (especially when used as an argument against one of the few people taking it seriously) I’d much rather have people who are open to listening than those who aren’t.

There’s the common question for older papers about definition. The various links to supplementary info and software also no longer work. There’s a lot I don’t understand but how they went about things sounds a little forced rather than following the data to me. Interesting to think about in the...