Search results

Treatment, an area I’ve avoided thinking too much about, but since the paper mentions it…. it looks like what we’d be hoping to do here is find something to stop the feedback loop? We’d then be back to our pre illness state (yey) but still presumably have a potential susceptibility for future...

For me it’s been absolutely fine with flu but terrible with the covid ones. So I assumed it’s more complex and related to specifics of antigen rather than just severity or anything which stimulates immune activity. But there’s also a question of systemic versus localised. Does the antigen need...

The more I listen to and think about this paper it does have the whiff of a Grand Unified Theory of chronic auto-inflammatory/immunity-like diseases. It would be good if it can start getting others outside the ME/CFS world interested. So how much this should be seen as a call to arms for the...

You’re right. Looks like it’s vitamin B2 (riboflavin) and B9 (folic acid) metabolites. May be relevant for them but was just a passing thought really.

May be worth reminding everyone of the blog post on the analysis plan. And here’s a direct link to the delicious pdf with all the details. I’m not going to pretend I understand it all, but there were bits I understand a bit more about now, compared to when the project started, thanks to my...

While reading up on MAIT cells I saw that they recognise vitamin B compounds. Could one reason that some of us respond well to doses of B 12 or B complexes be nothing to do with “energy” but that we’re giving MAIT cells something else to be interested in so distract some from their roles in this...

I think the proposal is more the timing of initiation of PEM after an action which triggers it and then some recovery time if there is no subsequent triggering event? The reference to damage may or may not be directly relevant but gives examples of these timings. I wonder if there could be...

Proof that marathons and ultramarathons are bad for your health! Interesting for the context of physical stress on the body though.

I’ve mainly been in recovery and digest mode. Looks like discussion is moving fast here, I need to catch up. But a couple of thoughts. As it fits in with and expands on much of what we’ve been talking about here in a clear framework, perhaps it’s unsurprising that I really like it. It’s an...

Virus-Induced Endothelial Senescence as a Cause and Driving Factor for ME/CFS and Long COVID: Mediated by a Dysfunctional Immune System Massimo Nunes, Loren Kell, Anouk Slaghekke, Rob Wüst, Burtram Fielding, Douglas Kell, Etheresia Pretorius Abstract Myalgic encephalomyelitis/chronic fatigue...

Haha, I mean, we could… Not using the pipeline I’ve setup though. I’m not sure it’s something I’d want to invest the time in to but… in theory yes we could. Voice cloning has got scarily good.

I’ve now had a first of no doubt many listens. This is great. I really enjoyed it, hope others do and of course most of all hope it gets the right people interested and thinking about the topic. Thanks to the three Jays!

Audio versions are available here https://u.pcloud.link/publink/show?code=kZLPeS5ZBEzVhhjXk8hM18y29vgEGVG6zSvk Any questions, comments or feedback please use this separate thread so we don’t distract from discussion of the paper. Thanks.

I’m sorting an audio version, a few pronunciation questions… “FcγRI” I’m going for “Fc gamma R one” “α1β4 integrin traffic domain”, “Alpha one beta four integrin traffic domain”? “MAIT cells are pronounced “mate” aren’t they? I think most of the others are initialised, things like GDF15, TNF...

That jumped out at me too, my understanding is this is a real thing, or rather the application of quantum mechanics to biology is. But like so much of the world of woo, people have taken it and re or misappropriated language and ideas and... *sigh*

They’re probably confused at all these hits to their archive page… refreshing looking for new papers. At least we know someone has found the admin password and they’re up and running again!

Putting the p value in parsnips?

Nice work @Sasha :thumbup: I’m just doing names for now.. how about Interferon Mediated T-cell Involved Resource Exhausting Disease Yes, I’m Tired

Complex pathways you say… Image source and more information here. Or slightly less scarily ‘what is an interferon?’

Excellent thank you. I can cope with probabilities, greys rather than black and whites. Combinations of complex interactions shifting this or that way. It seems to be how so much in the world works. You’ve often talked about this idea so it makes sense to have it explored more...