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Milligan’s Disease as in ‘I told you I was ill” (Ford) "you'd better be prepared for the jump into hyperspace. It's unpleasantly like being drunk." (Arthur) "What's so unpleasant about being drunk?" (Ford) "Ask a glass of water."

Or for more fun maybe we can find something that works for Gimlet or Gimli?

Gamma Receptor, Interferon Mediated, Nociceptor Exciting, Serious Syndrome

There does seem to be a good gap in the publishing archive since last Monday (with just one slipping in on Tuesday). Maybe everyone in the office took the week off? https://www.qeios.com/archive?type=article

Oh well in that case more questions! 1) How would this all fit in with Ryback et al’s findings of increased IGHV3-30 and skewing in the ratio of IgM to IgG BCRs seen in mild/moderate people and not in severe? 2) The basic mechanism seems to be of different cells all doing largely what we’d...

It’s well known that pasties cure all and my hypothalamus definitely has a clock which measures how long since I’ve had one. Or maybe it’s just the swede…

My first thought was that this could explain why I don’t know my antigen from my elbow… But maybe a nerve needs to know about localised things for other reasons. Perhaps its just a hangover that lots of cells have from earlier cell evolution. Or could it be that it’s useful for a nerve to know...

They only mention ME/CFS in passing in their abstract and conclusion, with the main focus being on fatigue and chronic fatigue.

Intelligent Eye Tracker Integrated with Cylindrical Capacitive Sensors for Chronic Fatigue Assessment Tianyi Li, Seo-Hyun Park, Changwoo Lee, Shawn Kim, Younghoon Kwon, Hojun Kim, Jae-Hyun Chung Abstract Fatigue negatively impacts health, safety, and productivity, yet current monitoring...

Genecards shows this for expression of FCGR1A https://www.genecards.org/cgi-bin/carddisp.pl?gene=FCGR1A#expression Maybe someone who has a better grip of this can get something useful from the expression atlas? https://www.ebi.ac.uk/gxa/home

Woohoo! Sunday has been a success. Thanks Jonathan and thank you to the greek gods of qeios for the extra time to digest information. This is all sounding very intriguing…

A couple more useful bits, I don’t seem to be able to edit my earlier post to add them now but… Bite Sized Immunology Phagocytosis https://www.immunology.org/public-information/bitesized-immunology/systems-processes/phagocytosis Complement System...

If you’ve been through the immunology basics and know what a phagocyte is but want to understand more about some of the processes they and other cells use are here are some resources. If you don’t know what a phagocyte is start here or check out the thread on Learning about the immune system...

Aha, receptor mediated endocytosis? Or am I suffering from ‘thing I just learnt about’ syndrome? edit: since this seems relevant, a description of this can be found here and I’ll post more in the Resources forum

I have been re-reading with more sleep and time to compost things. If I’m understanding the explanation… Macrophages are more likely to trigger because this FcgRI receptor has been bound to by an antibody? It’s sort of ‘primed’ by it? And this receptor is/can be expressed more when T cells are...

For the basics of T cells, B cells etc I’ve found the Khan Academy stuff in the other resource threads pretty good overviews. I’m not so sure about the visual aspects as I tend to just listen.They don’t seem to do the fluff to make things ‘engaging’ you get in some places. My feeling is if...

Thanks for the clarification Jonathan. I’ll sit back and wait for the full reveal of The Conspiracy of the Leukocytes

I should probably wait and go through the paper but if I’m understanding the summary (and I may not as I woke up at half 4 his morning)…. Some B cells create an antibody which binds to this specific receptor (Fc-gamma-RI) on certain cells, which means T cells get interested and fire off messages...

Just starting it off or also aggravating them some more? Would or could this theory explain why some immune triggers (illness or vaccination for example) also trigger worsening for some people?

I think FC Gamma RI (also called CD64 amongst other things) is a type of FC receptor Wikipedia entry Genecard Also see the wikipedia description of Fc gamma receptors